Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of nonalcoholic fatty liver disease
文献类型：期刊论文
| 作者 | Zhang LQ1,2; Wu XY1,3; Chang Q1; Xiao RY5; Liang B[*]1; Liao SS1,4; Li YH1; Zhang ZG1,2 |
| 刊名 | Biology Open
 |
| 出版日期 | 2016 |
| 卷号 | 5期号:10页码:1545-1552 |
| 关键词 | Nonalcoholic fatty liver disease (NAFLD) tree shrew (Tupaia belangeri chinensis) high energy diet animal model non-obese fatty liver |
| 通讯作者 | liangb@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Nonalcoholic fatty liver disease (NAFLD) is becoming a severe public health problem that is affecting a large proportion of population in the world. Generally, NAFLD patients are usually accompanied with obesity, hyperglycemia, insulin resistance (IR) and type 2 diabetes (T2D), for which numerous animal models have been generated in order to explore the pathogenesis and therapies of NAFLD. On the contrary, quite a number of NAFLD subjects especially in Asian regions are non-obese and non-diabetic. However, few animal models are available for the research of non-obese NAFLD. Here, four approaches (approach 1 to 4) divided by the variable compositions of diets were used to treat tree shrews (Tupaia belangeri chinensis), which have closer evolutionary relationship to primates than rodents. Analysis of plasma biochemical parameters, hepatic histology, and the expression of hepatic lipid metabolic genes revealed that all approaches led to hepatic lipid accumulation, liver injury and hypercholesterolemia; but had no effect on body weight and adipose tissue generation, as well as glycemia. Hepatic gene expression in tree shrews treated by approach 4 might suggest a different or non-canonical pathway leading to hepatic steatosis. In conclusion, the tree shrew displays hepatic steatosis, dyslipidemia, but non-obese and non-diabetic under high energy diets, which suggests that the tree shrew may be useful as a novel animal model for the research of human non-obese NAFLD. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences [grant no. XDB13030600], the National Natural Science FoundationofChina[grantno.U1202223,31171134andY301261041],theApplied Basic Research Foundation of Yunnan Province [grant no. 2014FB180], and Yunnan Oversea High-level Talents Program, Yunnan Provincial Science and Technology Department [grant no. 2015HA040 to B.L.]. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10503]  |
| 专题 | 昆明动物研究所_脂类代谢与疾病 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Science & Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 3.School of Life Sciences, Anhui University, Hefei, Anhui 230601, China 4.Key Laboratory of Puer Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, Yunnan 650201, China 5.Pharmaceutical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China |
| 推荐引用方式 GB/T 7714 | Zhang LQ,Wu XY,Chang Q,et al. Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of nonalcoholic fatty liver disease[J]. Biology Open,2016,5(10):1545-1552. |
| APA | Zhang LQ.,Wu XY.,Chang Q.,Xiao RY.,Liang B[*].,...&Zhang ZG.(2016).Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of nonalcoholic fatty liver disease.Biology Open,5(10),1545-1552. |
| MLA | Zhang LQ,et al."Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of nonalcoholic fatty liver disease".Biology Open 5.10(2016):1545-1552. |
入库方式： OAI收割
来源：昆明动物研究所
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