PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21(Cip1) signaling pathway
文献类型：期刊论文
| 作者 | Liu R1; Zhou ZM1,2; Huang JA3; Chen CS[*]1,2 |
| 刊名 | JOURNAL OF PATHOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 23期号:5页码:683-694 |
| 关键词 | PMEPA1 p21 c-Myc Smad3 prostate cancer |
| 通讯作者 | chenceshi@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | The PMEPA1 gene has been shown to suppress the androgen receptor (AR) and TGF beta signaling pathways and is abnormally expressed in prostate tumours. However, the role and mechanism action of PMEPA1 in AR-negative prostate cancer are unclear. Here, we demonstrate that inhibition of PMEPA1 suppresses AR-negative RWPE1 and PC-3 prostate cell proliferation through up-regulating the p21 transcription. Additionally, PMEPA1 overexpression suppresses the p21 expression and promotes cell proliferation. PMEPA1 is induced by TGF beta as a negative feedback loop to suppress Smad3 phosphorylation and nuclear translocation; up-regulates c-Myc; down-regulates p21; and promotes PC-3 cell proliferation. The PMEPA1 functions depend on its Smad2/3 binding motif. Consistently, depletion of Smad3/4, but not Smad2, blocks PMEPA1's functions of regulating c-Myc and p21. Importantly, stable depletion of PMEPA1 in PC-3 inhibits xenograft growth. Finally, we found that PMEPA1 is overexpressed in a subset of prostate cancer cell lines and tumours. These findings suggest that PMEPA1 may promote AR-negative prostate cancer cell proliferation through p21. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by a grant from the Department of Defense (W81XWH-07-1-0191), a grant from the American Cancer Society (RSG-08-199-01), and a grant from Yunnan Province High-Profile Tal- ents Project 2010 CI 114. Dr Liu is supported by a postdoctoral fellowship from the American Urological Association Foundation. |
| 语种 | 英语 |
| 公开日期 | 2011-04-25 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6601]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.The Center for Cell Biology and Cancer Research, MS355, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China, 650223 3.Lester and Sue Smith Breast Center, Baylor College of Medicine, BCM MS 600, One Baylor Plaza, Houston, TX 77030, USA |
| 推荐引用方式 GB/T 7714 | Liu R,Zhou ZM,Huang JA,et al. PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21(Cip1) signaling pathway[J]. JOURNAL OF PATHOLOGY,2011,23(5):683-694. |
| APA | Liu R,Zhou ZM,Huang JA,&Chen CS[*].(2011).PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21(Cip1) signaling pathway.JOURNAL OF PATHOLOGY,23(5),683-694. |
| MLA | Liu R,et al."PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21(Cip1) signaling pathway".JOURNAL OF PATHOLOGY 23.5(2011):683-694. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。