Progress of non-human primate animal models of cancers
文献类型：期刊论文
| 作者 | Xia HJ; Chen CS[*] |
| 刊名 | 动物学研究
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:1页码:70-80 |
| 关键词 | Non-human primate Cancer Tree shrew |
| 其他题名 | 非人灵长类肿瘤模型研究进展 |
| 通讯作者 | chenc@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 中文摘要 | 癌症是人类第二大致死的疾病。将体外细胞模型获得的癌症研究结果向临床转化过程中,动物活体实验是必不可少的一个环节。现在的肿瘤活体实验绝大部分采用啮齿类实验动物如小鼠和大鼠,这是因为它们具有个体小、繁殖迅速、遗传背景清楚、转基因技术成熟等优势。但是啮齿类和人的亲缘关系比较远,许多从啮齿类动物模型获得的研究结果不能在人体重现。非人灵长类动物在遗传进化、免疫、生理和代谢等诸多方面与人类高度近似,理论上更加适合癌症研究。本文对现有的非人灵长类肿瘤研究做一综述,主要集中介绍用化学和生物致癌剂在不同的非人灵长类动物诱导肿瘤的研究,为将来用非人灵长类动物研究人类癌症奠定基础。 |
| 英文摘要 | Cancer is the second leading disease causing human death. Pre-clinical in vivo studies are essential for translating in vitro laboratory research results into the clinic. Rodents, including the mouse and rat, have been widely used for pre-clinical studies due to their small size, clear genetic backgrounds, rapid propagation, and mature transgenic technologies. However, because rodents are evolutionarily distinct from humans, many pre-clinical research results using rodent models cannot be reproduced in the clinic. Non-human primates (NHPs) may be better animal models than rodents for human cancer research because NHPs and humans share greater similarity in regards to their genetic evolution, immune system, physiology and metabolism. This article reviews the latest progress of cancer research in NHPs by focusing on the carcinogenesis of different NHPs induced by chemical and biological carcinogens. Finally, future research directions for the use of NHPs in cancer research are discussed. |
| 收录类别 | 其他 |
| 资助信息 | supported in part by a grant from Yunnan Province High-Profile Talent Project 2010CI114;grants from Chinese Academy of Sciences(Basic frontier project,KSCX2-EW-J-23). |
| 语种 | 英语 |
| 公开日期 | 2011-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6692]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Xia HJ,Chen CS[*]. Progress of non-human primate animal models of cancers[J]. 动物学研究,2011,32(1):70-80. |
| APA | Xia HJ,&Chen CS[*].(2011).Progress of non-human primate animal models of cancers.动物学研究,32(1),70-80. |
| MLA | Xia HJ,et al."Progress of non-human primate animal models of cancers".动物学研究 32.1(2011):70-80. |
入库方式： OAI收割
来源：昆明动物研究所
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