热门
WWP1: a versatile ubiquitin E3 ligase in signaling and diseases
文献类型：期刊论文
| 作者 | Zhi X1,2; Chen CS[*]1 |
| 刊名 | CELLULAR AND MOLECULAR LIFE SCIENCES
 |
| 出版日期 | 2012 |
| 卷号 | 69期号:9页码:1425-1434 |
| 关键词 | WWP1 WW domain PY motif Ubiquitin E3 ligase Ubiquitination Cancer |
| 通讯作者 | chenc@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is a multifunction protein containing an N-terminal C2 domain, four tandem WW domains for substrate binding, and a C-terminal catalytic HECT domain for ubiquitin transferring. WWP1 has been suggested to function as the E3 ligase for several PY motif-containing proteins, such as Smad2, KLF5, p63, ErbB4/HER4, RUNX2, JunB, RNF11, SPG20, and Gag, as well as several non-PY motif containing proteins, such as TβR1, Smad4, KLF2, and EPS15. WWP1 regulates a variety of cellular biological processes including protein trafficking and degradation, signaling, transcription, and viral budding. WWP1 has been implicated in several diseases, such as cancers, infectious diseases, neurological diseases, and aging. In this review article, we extensively summarize the current knowledge of WWP1 with special emphasis on the roles and action of mechanism of WWP1 in signaling and human diseases. |
| 收录类别 | SCI |
| 资助信息 | This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114). |
| 语种 | 英语 |
| WOS记录号 | WOS:000303408800003 |
| 公开日期 | 2012-09-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7016]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zool 2.The Center for Cell Biology and Cancer Research, Albany Medical College, 47, New Scotland Ave., Albany, NY 12208, USA |
| 推荐引用方式 GB/T 7714 | Zhi X,Chen CS[*]. WWP1: a versatile ubiquitin E3 ligase in signaling and diseases[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2012,69(9):1425-1434. |
| APA | Zhi X,&Chen CS[*].(2012).WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.CELLULAR AND MOLECULAR LIFE SCIENCES,69(9),1425-1434. |
| MLA | Zhi X,et al."WWP1: a versatile ubiquitin E3 ligase in signaling and diseases".CELLULAR AND MOLECULAR LIFE SCIENCES 69.9(2012):1425-1434. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。