Characterization of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis)
文献类型：期刊论文
| 作者 | Xia HJ1; Wang CY1,2,3; Zhang HL1; He BL3; Jiao JL3; Chen CS[*]1 |
| 刊名 | Zoological Research
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:1页码:55-59 |
| 关键词 | Spontaneous breast cancer Tree shrew Immunohistochemistry |
| 其他题名 | 自发性树鼩乳腺肿瘤的特性 |
| 通讯作者 | chenc@mail.kiz.ac.cn |
| 中文摘要 | 乳腺癌是严重危害女性健康的常见恶性肿瘤,建立合适的乳腺癌动物模型对于研究人类乳腺癌的生物学机制及发展新的防治方法至关重要。相对于常用的啮齿类动物,树鼩(Tupaia belangeri chinensis,tree shrew)因在进化层次上更接近于人类而可用于建立更适合的乳腺癌模型。该文详细了介绍一例树鼩自发性乳头状良性乳腺肿瘤。免疫组化结果显示该例肿瘤孕激素受体阳性且Ki-67阳性细胞比例显著增加;而活化的Caspase3阳性细胞比例较低;且肿瘤的形态和病理与人导管内乳头状肿瘤非常接近。提示利用树鼩建立乳腺肿瘤模型的可行性。 |
| 英文摘要 | Breast cancer is a common malignant tumor. It is essential to develop suitable animal models for discovering novel preventive and therapeutic approaches. Tree shrews (Tupaia belangeri chinensis) have a closer evolutionary relationship with humans than do rodents, which have been widely used in laboratory research. Spontaneous breast tumors were identified in tree shrews in 1960s; however, no detailed studies about tree shrew breast tumors have been conducted to date. Here, we characterized a spontaneous breast tumor from tree shrews by Haematoxylin Eosin (H&E) staining. This tumor was identified as a papillary tumor. Immunohistochemical staining (IHC) for progesterone receptor (PR), Ki-67 and cleaved caspase-3 showed that tumor cells were positive for PR, highly proliferative, and less apoptotic compared to normal breast epithelial cells. Thus, the spontaneous tumor of tree shrew is very close to human papillary tumors in terms of morphology and pathology and we concluded that tree shrew may be a suitable animal model for breast cancer research. |
| 收录类别 | CSCD |
| 资助信息 | Yunnan Province High-Profile Talent Project (2010CI114);the Chinese Academy of Sciences,Basic Frontier Project (KSCX2-EW-J-23). |
| 语种 | 英语 |
| 公开日期 | 2012-09-06 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7035]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 3.Kunming Medical University, Kunming, 650031, China |
| 推荐引用方式 GB/T 7714 | Xia HJ,Wang CY,Zhang HL,et al. Characterization of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis)[J]. Zoological Research,2012,33(1):55-59. |
| APA | Xia HJ,Wang CY,Zhang HL,He BL,Jiao JL,&Chen CS[*].(2012).Characterization of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis).Zoological Research,33(1),55-59. |
| MLA | Xia HJ,et al."Characterization of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis)".Zoological Research 33.1(2012):55-59. |
入库方式： OAI收割
来源：昆明动物研究所
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