RNF115/BCA2 E3 Ubiquitin Ligase Promotes Breast Cancer Cell Proliferation through Targeting p21(Waf1/Cip1) for Ubiquitin-Mediated Degradation
文献类型：期刊论文
| 作者 | Wang ZH1; Nie Z2; Chen WL3; Zhou ZM1; Kong QH1; Seth AK4; Liu R[*]1; Chen CS[*]1 |
| 刊名 | NEOPLASIA
 |
| 出版日期 | 2013 |
| 卷号 | 15期号:9页码:1028-1035 |
| 通讯作者 | liurong@mail.kiz.ac.cn ; chenc@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | The E3 ubiquitin ligase RING finger protein 115 (RNF115), also known as breast cancer-associated gene 2 (BCA2), has previously been reported to be overexpressed in estrogen receptor alpha (ER alpha)-positive breast tumors and to promote breast cell proliferation; however, its mechanism is unknown. In this study, we demonstrated that silencing of BCA2 by small interfering RNAs (siRNAs) in two ER alpha-positive breast cancer cell lines, MCF-7 and T47D, decreases cell proliferation and increases the protein levels of the cyclin-dependent kinase inhibitor p21(Waf/Cip1). The protein stability of p21 was negatively regulated by BCA2. BCA2 directly interacts with p21 and promotes p21 ubiquitination and proteasomal degradation. Knockdown of p21 partially rescues the cell growth arrest induced by the BCA2 siRNA. These results suggest that BCA2 promotes ER alpha-positive breast cancer cell proliferation at least partially through downregulating the expression of p21. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by National Key Basic Research Program of China (2013CB910900), National Natural Science Foundation of China (81072162, 81120108019, 81272930, and U1132605), Top Talents Program of Yunnan Province, China (2010CI114), Science and Technological Key Project of Yunnan Province (2012FB185), and “Western Light” Talents Training Program of Chinese Academy of Sciences (to Q.K.). |
| 语种 | 英语 |
| WOS记录号 | WOS:000328134800004 |
| 公开日期 | 2014-01-13 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7771]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 3.Department of Breast, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 4.Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada |
| 推荐引用方式 GB/T 7714 | Wang ZH,Nie Z,Chen WL,et al. RNF115/BCA2 E3 Ubiquitin Ligase Promotes Breast Cancer Cell Proliferation through Targeting p21(Waf1/Cip1) for Ubiquitin-Mediated Degradation[J]. NEOPLASIA,2013,15(9):1028-1035. |
| APA | Wang ZH.,Nie Z.,Chen WL.,Zhou ZM.,Kong QH.,...&Chen CS[*].(2013).RNF115/BCA2 E3 Ubiquitin Ligase Promotes Breast Cancer Cell Proliferation through Targeting p21(Waf1/Cip1) for Ubiquitin-Mediated Degradation.NEOPLASIA,15(9),1028-1035. |
| MLA | Wang ZH,et al."RNF115/BCA2 E3 Ubiquitin Ligase Promotes Breast Cancer Cell Proliferation through Targeting p21(Waf1/Cip1) for Ubiquitin-Mediated Degradation".NEOPLASIA 15.9(2013):1028-1035. |
入库方式： OAI收割
来源：昆明动物研究所
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