The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8
文献类型：期刊论文
| 作者 | Li Y1,2; Kong Y1; Zhou Z1; Chen H3; Wang Z1; Hsieh YC4; Zhao D4; Zhi X4; Huang J5; Zhang J3 |
| 刊名 | CELL DEATH & DISEASE
 |
| 出版日期 | 2013 |
| 卷号 | 4期号:X页码:e935 |
| 关键词 | ubiquitination apoptosis breast cancer HECTD3 caspase-8 |
| 通讯作者 | chenc@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Apoptosis resistance is a hurdle for cancer treatment. HECTD3, a new E3 ubiquitin ligase, interacts with caspase-8 death effector domains and ubiquitinates caspase-8 with K63-linked polyubiquitin chains that do not target caspase-8 for degradation but decrease the caspase-8 activation. HECTD3 depletion can sensitize cancer cells to extrinsic apoptotic stimuli. In addition, HECTD3 inhibits TNF-related apoptosis-inducing ligand (TRAIL)-induced caspase-8 cleavage in an E3 ligase activity-dependent manner. Mutation of the caspase-8 ubiquitination site at K215 abolishes the HECTD3 protection from TRAIL-induced cleavage. Finally, HECTD3 is frequently overexpressed in breast carcinomas. These findings suggest that caspase-8 ubiquitination by HECTD3 confers cancer cell survival. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327760500033 |
| 公开日期 | 2014-09-26 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8010]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China 3.Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA 4.The Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Ave, Albany, NY 12208, USA 5.Department of Pathology, Medical College of Wisconsin, Milwaukee, WI 53226,USA 6.DepartmentofBiomedicalSciences,SchoolofPublicHealth,UniversityatAlbany,StateUniversityofNewYork,POBox509,Albany,NY12201,USA |
| 推荐引用方式 GB/T 7714 | Li Y,Kong Y,Zhou Z,et al. The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8[J]. CELL DEATH & DISEASE,2013,4(X):e935. |
| APA | Li Y.,Kong Y.,Zhou Z.,Chen H.,Wang Z.,...&Chen C[*].(2013).The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8.CELL DEATH & DISEASE,4(X),e935. |
| MLA | Li Y,et al."The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8".CELL DEATH & DISEASE 4.X(2013):e935. |
入库方式： OAI收割
来源：昆明动物研究所
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