WWOX suppresses KLF5 expression and breast cancer cell growth
文献类型：期刊论文
| 作者 | Ge F1; Chen WL2; Yang RX3; Zhou ZM4; Chang NS5; Chen CS4; Zou TN2; Liu R4; Tan J[*]2; Ren GS[*]1 |
| 刊名 | CHINESE JOURNAL OF CANCER RESEARCH
 |
| 出版日期 | 2014 |
| 卷号 | 26期号:5页码:511-516 |
| 关键词 | WW domain-containing oxidoreductase (WWOX) KLF5 breast cancer |
| 通讯作者 | rgs726@163.com ; kmtjing@sina.com |
| 合作状况 | 其它 |
| 英文摘要 | The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor in a variety of cancers, including breast cancer. Reduced WWOX expression is associated with the basal-like subtype and a relatively poor disease-free survival rate among breast cancer patients. Though several WWOX partners have been identified, the functional mechanisms of WWOX's role in cancers have not been fully addressed to date. In the current study, we found WWOX suppresses expression of KLF5-an oncogenic transcription factor at protein level, and suppresses cancer cell proliferation in both bladder and breast cancer cell lines. Furthermore, we demonstrated that WWOX physically interacts with KLF5 via the former's WW domains and the latter's PY motifs. Interestingly, we found the expression of WWOX negatively correlates with KLF5 expression in a panel of breast cancer cell lines. Taken together, we conjecture that WWOX may suppress cancer cell proliferation partially by reducing the expression of KLF5. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by National Natural Science Foundation of China (81272930, 81322038, 31260208, and U1132605), the Science and Technological Key Project of Yunnan Province (2012FB185) and West Light Foundation of the Chinese Academy of Sciences (to R.L.). |
| 语种 | 英语 |
| WOS记录号 | WOS:000344976400002 |
| 公开日期 | 2014-12-19 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8200]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China 2.Department of Breast Surgery,The 3rd Affiliated Hospital of Kunming Medical University, Kunming 650118, China 3.Second Department of Internal Medicine of Oncology, The 3rd Affiliated Hospital of Kunming Medical University, Kunming 650118, China 4.Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China 5.Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, China |
| 推荐引用方式 GB/T 7714 | Ge F,Chen WL,Yang RX,et al. WWOX suppresses KLF5 expression and breast cancer cell growth[J]. CHINESE JOURNAL OF CANCER RESEARCH,2014,26(5):511-516. |
| APA | Ge F.,Chen WL.,Yang RX.,Zhou ZM.,Chang NS.,...&Ren GS[*].(2014).WWOX suppresses KLF5 expression and breast cancer cell growth.CHINESE JOURNAL OF CANCER RESEARCH,26(5),511-516. |
| MLA | Ge F,et al."WWOX suppresses KLF5 expression and breast cancer cell growth".CHINESE JOURNAL OF CANCER RESEARCH 26.5(2014):511-516. |
入库方式： OAI收割
来源：昆明动物研究所
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