Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms
文献类型：期刊论文
| 作者 | Ge GZ[1,2; Xu TR[*]1; Chen CS[*]2 |
| 刊名 | Acta Biochim Biophys Sin (Shanghai)
 |
| 出版日期 | 2015 |
| 卷号 | 47期号:7页码:477-487 |
| 关键词 | NNK animal model lung cancer oncogenic mechanisms |
| 通讯作者 | chenc@mail.kiz.ac.cn ; xtrgfq@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Tobacco usage is a major risk factor in the development, progression, and outcomes for lung cancer. Of the carcinogens associated with lung cancer, tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is among the most potent ones. The oncogenic mechanisms of NNK are not entirely understood, hindering the development of effective strategies for preventing and treating smoking-associated lung cancers. Here, we introduce the NNK-induced lung cancer animal models in different species and its potential mechanisms. Finally, we summarize several chemopreventive agents developed from these animal models. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by grants from the National High-tech R&D Program of China (863 Program) (Nos. 2012AA021801 and 2012AA022402) from Ministry of Science and Technology of China and the National Natural Science Foundation of China (Nos. 81202110, 81120108019, U1132605, and 81325016). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9361]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Facultyof Life Science and Technology, Kunming Universityof Science and Technology, Kunming 650500, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Ge GZ[,Xu TR[*],Chen CS[*]. Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms[J]. Acta Biochim Biophys Sin (Shanghai),2015,47(7):477-487. |
| APA | Ge GZ[,Xu TR[*],&Chen CS[*].(2015).Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms.Acta Biochim Biophys Sin (Shanghai),47(7),477-487. |
| MLA | Ge GZ[,et al."Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms".Acta Biochim Biophys Sin (Shanghai) 47.7(2015):477-487. |
入库方式： OAI收割
来源：昆明动物研究所
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