Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)
文献类型：期刊论文
| 作者 | Ge F1,2; Chen WL3; Qin JY1; Zhou ZM1; Liu R1; Liu LL4; Tan J3; Zou TN3; Li HY2; Ren GS[*]2 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:25页码:21369-21378 |
| 关键词 | ATXN3L KLF5 breast cancer DUB |
| 通讯作者 | rgs726@163.com |
| 合作状况 | 其它 |
| 英文摘要 | The Krüppel-like factor 5 (KLF5) has been suggested to promote breast cell proliferation, survival and tumorigenesis. KLF5 protein degradation is increased by several E3 ubiquitin ligases, including WWP1 and SCFFbw7, through the ubiquitin-proteasome pathway. However, the deubiquitinase (DUB) of KLF5 has not been demonstrated. In this study, we identified ATXN3L as a KLF5 DUB by genome-wide siRNA screening. ATXN3L directly binds to KLF5, decreasing its ubiquitination and thus degradation. Functionally, knockdown of ATXN3L inhibits breast cancer cell proliferation partially through KLF5. These findings reveal a previously unrecognized role of ATXN3L in the regulation of KLF5 stability in breast cancer. ATXN3L might be a therapeutic target for breast cancer. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Key Basic Research Program of China (2013CB910900), the Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), and the National Natural Science Foundation of China (81120108019, 81325016, U1132605, and 31260208). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9376]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 3.Department of Breast Surgery, The 3rd Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 4.Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming, China |
| 推荐引用方式 GB/T 7714 | Ge F,Chen WL,Qin JY,et al. Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)[J]. ONCOTARGET,2015,6(25):21369-21378. |
| APA | Ge F.,Chen WL.,Qin JY.,Zhou ZM.,Liu R.,...&Chen CS[*].(2015).Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5).ONCOTARGET,6(25),21369-21378. |
| MLA | Ge F,et al."Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)".ONCOTARGET 6.25(2015):21369-21378. |
入库方式： OAI收割
来源：昆明动物研究所
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