Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression
文献类型：期刊论文
| 作者 | Liu R[*]1; Shi PG1; Chen WL3; Chen HJ4; Dong C5; Yang RX5; Liu SL6; Chen CS[*]1; Nie Z2; Liang HC1 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:4页码:533-544 |
| 关键词 | Triple-negative Breast Cancer Mifepristone Cancer Stem Cell KLF5 miR-153 |
| 通讯作者 | liurong@mail.kiz.ac.cn ; chenc@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast cancers without effective targeted therapies. Mifepristone (MIF), a drug regularly used for abortion, has been reported to have anti-tumor activity in multiple hormone-dependent cancers, including luminal type breast cancers. In this study, we showed that MIF suppressed tumor growth of the TNBC cell lines and patient-derived xenografts in NOD-SCID mice. Furthermore, MIF reduced the TNBC cancer stem cell (CSC) population through down-regulating KLF5 expression, a stem cell transcription factor over-expressed in basal type TNBC and promoting cell proliferation, survival and stemness. Interestingly, MIF suppresses the expression of KLF5 through inducing the expression of miR-153. Consistently, miR-153 decreases CSC and miR-153 inhibitor rescued MIF-induced down-regulation of the KLF5 protein level and CSC ratio. Taken together, our findings suggest that MIF inhibits basal TNBC via the miR-153/KLF5 axis and MIF may be used for the treatment of TNBC. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by Strategic Priority Research Program of the Chinese Academy of Sci- ences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81322038, 81272930, 81325016, 81120108019, U1132605 and U1502222), Yunnan Applied Basic Re- search Key Projects (2015FA027), West Light Founda- tion of Chinese Academy of Sciences (to R.L.), Youth Innovation Promotion Association, Chinese Academy of Sciences (to R.L.), and Changsha Science and Technology Program Key Projects (K1406209-31). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9537]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Kunming Institute of Zoology, Chinese Academy of Sciences, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming, 650223, China 2.Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China 3.Department of Breast surgery, the 3rd affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China 4.College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, 350108, China 5.Department of the second medical oncology, the 3rd affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China 6.Institute for Cancer Research, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science & Technology of China, Hefei, Anhui, 230027, China. |
| 推荐引用方式 GB/T 7714 | Liu R[*],Shi PG,Chen WL,et al. Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression[J]. THERANOSTICS,2016,6(4):533-544. |
| APA | Liu R[*].,Shi PG.,Chen WL.,Chen HJ.,Dong C.,...&Zhou ZM.(2016).Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression.THERANOSTICS,6(4),533-544. |
| MLA | Liu R[*],et al."Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression".THERANOSTICS 6.4(2016):533-544. |
入库方式： OAI收割
来源：昆明动物研究所
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