KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway
文献类型：期刊论文
| 作者 | Kong YJ1,2; Li FB1,2; Qiu MH[*]3; Chen CS[*]1; Nian Y1,3; Zhou ZM1; Yang RX[*]4 |
| 刊名 | Theranostics
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:6页码:875-886 |
| 关键词 | KHF16 Cycloartane triterpenoid Triple negative breast cancer Cell cycle NF-κ Apoptosis |
| 通讯作者 | jenny_yrx@sohu.com ; qiuminghua@mail.kib.ac.cn ; chenc@mail.kiz.ac.cn |
| 英文摘要 | Triterpenoids extracted from Cimicifuga foetida have been reported to inhibit cancer by inducing cell cycle arrest and apoptosis. In this study, KHF16 (24-acetylisodahurinol-3-O-β-D-xylopyranoside), a cycloartane triterpenoid isolated from the rhizomes of C. foetida, showed potent anti-cancer activity in multiple ERα/PR/HER2 triple-negative breast cancer (TNBC) cell lines. KHF16 significantly induces cell cycle G2/M phase arrest and apoptosis in both MDA-MB-468 and SW527 TNBC cell lines. KHF16 reduces the expression levels of XIAP, Mcl-1, Survivin and Cyclin B1/D1 proteins. Importantly, KHF16 inhibits TNFα-induced IKKα/β phosphorylation, IKBα phosphorylation, p65 nuclear translocation and NF-κB downstream target gene expression, including XIAP, Mcl-1 and Survivin, in TNBC cells. These results suggest that KHF16 may inhibit TNBC by blocking the NF-κB signaling pathway in part. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (81120108019 and 81325016 to Chen, C; U1192604 and 39970086 to Qiu, M.; 81560432 to Yang, R., 81402206 to Kong, Y.; 81302670 to Nian, Y.). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9738]  |
| 专题 | 昆明动物研究所_肿瘤生物学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204 Yunnan, China 3.tate Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204 Yunnan, China 4.Department of the second medical oncology, the 3rd affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China |
| 推荐引用方式 GB/T 7714 | Kong YJ,Li FB,Qiu MH[*],et al. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway[J]. Theranostics,2016,6(6):875-886. |
| APA | Kong YJ.,Li FB.,Qiu MH[*].,Chen CS[*].,Nian Y.,...&Yang RX[*].(2016).KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway.Theranostics,6(6),875-886. |
| MLA | Kong YJ,et al."KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway".Theranostics 6.6(2016):875-886. |
入库方式： OAI收割
来源：昆明动物研究所
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