Cancer therapy in the necroptosis era
文献类型：期刊论文
| 作者 | Su Z1,2; Yang Z[*]3; Xie L3; DeWitt JP2; Chen Y4 |
| 刊名 | CELL DEATH AND DIFFERENTIATION
 |
| 出版日期 | 2016 |
| 卷号 | 23期号:5页码:748-756 |
| 通讯作者 | yangzuozhang@163.com |
| 合作状况 | 其它 |
| 英文摘要 | Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase domain-like protein (MLKL). Recently, necroptosis-based cancer therapy has been proposed to be a novel strategy for antitumor treatment. However, a big controversy exists on whether this type of therapy is feasible or just a conceptual model. Proponents believe that because necroptosis and apoptosis use distinct molecular pathways, triggering necroptosis could be an alternative way to eradicate apoptosis-resistant cancer cells. This hypothesis has been preliminarily validated by recent studies. However, some skeptics doubt this strategy because of the intrinsic or acquired defects of necroptotic machinery observed in many cancer cells. Moreover, two other concerns are whether or not necroptosis inducers are selective in killing cancer cells without disturbing the normal cells and whether it will lead to inflammatory diseases. In this review, we summarize current studies surrounding this controversy on necroptosis-based antitumor research and discuss the advantages, potential issues, and countermeasures of this novel therapy. |
| 收录类别 | SCI |
| 资助信息 | This research was supported, in part, by grants from the NationalNaturalScienceFoundationofChina(Nos81460440,31300666,81260322, 81372322 and 81560471), the China Postdoctoral Science Foundation (Nos 2013M542478 and 2015T81139), the Natural Science Foundation of Yunnan Province (No. 2012FB163), the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University (No. 2014FB059), the Scientific Research Projects from Internal Research Institutions of Medical and Health Units in Yunnan Province (Nos 2014NS013, 2014NS014, 2014NS015, and 2014NS016), Foundation of the Yunnan Provincial Innovative Team of Bone and Soft TissueTumor (No.2015HC026), Foundation of the Young and Middle-aged Academic and Technical Leaders of Yunnan Province (No.2014HB034), and Doctor Scientific ResearchStartupFundsoftheThirdAffiliatedHospitalofKunmingMedicalUniversity (No. BSJJ201406). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9540]  |
| 专题 | 昆明动物研究所_肿瘤信号转导 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Department of Biochemistry and Molecular Biology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China 2.Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA 3.Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China 4.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Su Z,Yang Z[*],Xie L,et al. Cancer therapy in the necroptosis era[J]. CELL DEATH AND DIFFERENTIATION,2016,23(5):748-756. |
| APA | Su Z,Yang Z[*],Xie L,DeWitt JP,&Chen Y.(2016).Cancer therapy in the necroptosis era.CELL DEATH AND DIFFERENTIATION,23(5),748-756. |
| MLA | Su Z,et al."Cancer therapy in the necroptosis era".CELL DEATH AND DIFFERENTIATION 23.5(2016):748-756. |
入库方式： OAI收割
来源：昆明动物研究所
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