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  5. 重大疾病机理的遗传学
A critical reassessment of the role of mitochondria in tumorigenesis

文献类型：期刊论文

作者Salas A[*]1,2; Yao YG3; Macaulay V4; Vega A2,5; Carracedo A1,2,5; Bandelt HJ6
刊名PLOS MEDICINE
出版日期2005
卷号2期号:11页码:1158-1166
ISSN号1549-1277
通讯作者apimlase@usc.es
合作状况其它
英文摘要Background Mitochondrial DNA (mtDNA) is being analyzed by an increasing number of laboratories in order to investigate its potential role as an active marker of tumorigenesis in various types of cancer. Here we question the conclusions drawn in most of these investigations, especially those published in high-rank cancer research journals, under the evidence that a significant number of these medical mtDNA studies are based on obviously flawed sequencing results. Methods and Findings In our analyses, we take a phylogenetic approach and employ thorough database searches, which together have proven successful for detecting erroneous sequences in the fields of human population genetics and forensics. Apart from conceptual problems concerning the interpretation of mtDNA variation in tumorigenesis, in most cases, blocks of seemingly somatic mutations clearly point to contamination or sample mix-up and, therefore, have nothing to do with tumorigenesis. Conclusion The role of mitochondria in tumorigenesis remains unclarified. Our findings of laboratory errors in many contributions would represent only the tip of the iceberg since most published studies do not provide the raw sequence data for inspection, thus hindering a posteriori evaluation of the results. There is no precedent for such a concatenation of errors and misconceptions affecting a whole subfield of medical research.
收录类别SCI
资助信息This work was supported by grants from the Ministerio de Sanidad y Consumo (Fondo de Investigacio ´n Sanitaria; Instituto de Salud Carlos III, PI030893; SCO/3425/2002) and Genoma Espan ˜a (CeGen; Centro Nacional de Genotipado).
原文出处200521158.pdf
语种英语
公开日期2010-08-24
源URL[http://159.226.149.42:8088/handle/152453/5979]  
专题昆明动物研究所_重大疾病机理的遗传学
昆明动物研究所_细胞与分子进化重点实验室
作者单位1.Unidade de Xenetica, Instituto de Medicina Legal, Facultade de Medicina, Universidad de Santiago de Compostela, Galicia, Spain
2.Centro Nacional de Genotipado (CeGen), Hospital Clı ´nico Universitario, Santiago de Compostela, Galicia, Spain
3.Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
4.Department of Statistics, University of Glasgow, Glasgow, Scotland, United Kingdom
5.Fundacion Publica Galega de Medicina Xeno ´mica (FPGMX), Hospital Clı ´nico Universitario, Universidad de Santiago de Compostela, Galicia, Spain
6.Department of Mathematics, University of Hamburg, Hamburg, Germany
推荐引用方式
GB/T 7714		 Salas A[*],Yao YG,Macaulay V,et al. A critical reassessment of the role of mitochondria in tumorigenesis[J]. PLOS MEDICINE,2005,2(11):1158-1166.
APA Salas A[*],Yao YG,Macaulay V,Vega A,Carracedo A,&Bandelt HJ.(2005).A critical reassessment of the role of mitochondria in tumorigenesis.PLOS MEDICINE,2(11),1158-1166.
MLA Salas A[*],et al."A critical reassessment of the role of mitochondria in tumorigenesis".PLOS MEDICINE 2.11(2005):1158-1166.

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来源：昆明动物研究所

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