IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders
文献类型：期刊论文
| 作者 | Zou Y1,4; Zeng Y2; Zhang DF1,4; Zou SH3; Cheng YF[*]3; Yao YG[*]1 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2010 |
| 卷号 | 402期号:2页码:378-383 |
| 关键词 | IDH1 IDH2 Mutation Hematological malignancies Chinese |
| 通讯作者 | cheng.yunfeng@zs-hospital.sh.cn ; ygyaozh@g-mail.com |
| 合作状况 | 其它 |
| 英文摘要 | Frequent mutations in the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) have been identified in gliomas and acute myeloid leukemia (AML). Our aim is to assess whether IDH mutations were presented in Chinese patients with various hematological disorders. In this study, we screened the IDH1 and IDH2 mutations in a cohort of 456 Chinese patients with various hematological malignancies and disorders. We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene. Except for one non-Hodgkin lymphoma (NHL) patient harboring IDH1 mutation p.R132C, all IDH1 and IDH2 missense mutations were observed in patients with AML Intriguingly, the IDH2 mutation p.R140Q and novel IDH1 mutation p.I99M co-occurred in a 75-year-old patient with AML developed from myelodysplastic syndromes (MDS). The frequency of IDH1 and IDH2 missense mutations in Chinese AML patients reached 5.9% and 8.3%, respectively. Our results supported the recent findings that IDH gene mutations were common in AML Conversely, IDH mutations were rather rare in Chinese patients with other types of hematological disorders. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Natural Science Foundation of China (30925021 and 81060046), Yunnan Province (2009CI119), and the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 公开日期 | 2010-12-20 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6551]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Department of Hematology, the First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China 3.Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China 4.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China |
| 推荐引用方式 GB/T 7714 | Zou Y,Zeng Y,Zhang DF,et al. IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,402(2):378-383. |
| APA | Zou Y,Zeng Y,Zhang DF,Zou SH,Cheng YF[*],&Yao YG[*].(2010).IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,402(2),378-383. |
| MLA | Zou Y,et al."IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402.2(2010):378-383. |
入库方式： OAI收割
来源：昆明动物研究所
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