Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients
文献类型：期刊论文
| 作者 | Xiao MS1,2; Zhang DF1,2; Zeng Y3; Cheng YF4; Yao YG[*]1 |
| 刊名 | ANNALS OF HEMATOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 90期号:10页码:1137-1144 |
| 关键词 | CASP8 Chinese Non-Hodgkin's lymphoma SNP Genetic susceptibility |
| 通讯作者 | ygyaozh@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Caspase-8 (CASP8) involved in apoptosis plays an important role in mediating the normal regulation of cell proliferation, differentiation, inflammation, and homeostasis of multicellular organisms. Genetic polymorphisms, rs3834129 (-/CTTACT) and rs3769821 (T/C), in the promoter region of different CASP8 transcripts, were reported to be associated with genetic susceptibility of multiple cancers and non-Hodgkin's lymphoma (NHL), respectively. To investigate whether these two genetic variants, together with rs113686495 (-/CTGTCATT) which is 50 bp downstream of rs3769821, were associated with NHL in Chinese patients, we genotyped two cohorts of case and control samples from Kunming (case n = 64, control n = 133) and Shanghai (case n = 75, control n = 107). Luciferase assays were further performed to characterize the potential role of different alleles in the promoter region of the CASP8 gene. In contrast to previous studies, we found no difference regarding the genotypes and haplotypes of rs3834129, rs3769821, and rs113686495 between the case and control samples. Luciferase assays of the promoter regions harboring different alleles of these three variants also showed no difference. Our negative results gave no support for an active role for these genetic variants in conferring NHL in Chinese patients. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Natural Science Foundation of China (30925021), Yunnan Province (2009CI119), and the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 公开日期 | 2011-09-23 |
| 源URL | [http://159.226.149.42:8088/handle/353002/6809]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, Chin 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 3.Department of Hematology, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan 650032, China 4.Department of Hematology, Zhongshan Hospital Fudan University, Shanghai 200032, China |
| 推荐引用方式 GB/T 7714 | Xiao MS,Zhang DF,Zeng Y,et al. Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients[J]. ANNALS OF HEMATOLOGY,2011,90(10):1137-1144. |
| APA | Xiao MS,Zhang DF,Zeng Y,Cheng YF,&Yao YG[*].(2011).Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients.ANNALS OF HEMATOLOGY,90(10),1137-1144. |
| MLA | Xiao MS,et al."Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin's lymphoma in Chinese patients".ANNALS OF HEMATOLOGY 90.10(2011):1137-1144. |
入库方式： OAI收割
来源：昆明动物研究所
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