Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China
文献类型：期刊论文
| 作者 | Wang D1,5; Feng JQ1,4; Li YY2; Zhang DF1,5; Li XA3; Li QW4; Yao YG[*]1 |
| 刊名 | HUMAN GENETICS
 |
| 出版日期 | 2012 |
| 卷号 | 131期号:7页码:1251-1260 |
| 通讯作者 | ygyaozh@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Leprosy is an ancient infectious disease, with over 200,000 affected people (mainly in Asia and Africa) being registered annually. Genetic factors may confer susceptibility to this disease. In the present study, we genotyped 12 genetic variants of the MRC1 gene and the IFNG gene in 527 Han Chinese with leprosy and 583 healthy individuals from Yunnan, China, to discern potential association of these two genes with leprosy. In particular, we aimed to validate the recently reported association of MRC1 variant rs1926736 (p.G396S) and IFNG variant rs2430561 (+874 T > A) with leprosy, which were initially observed in Vietnamese and Brazilian populations, respectively. Our results failed to confirm the reported association between variants rs1926736 and rs2430561 and leprosy in Han Chinese. However, we found that variants rs692527 (P = 0.022) and rs34856358 (P = 0.022) of the MRC1 gene were associated with paucibacillary leprosy, and rs3138557 of the IFNG gene was significantly associated with multibacillary leprosy. The exact role of the MRC1 gene and the IFNG gene in leprosy awaits future study. |
| 收录类别 | SCI |
| 资助信息 | We are grateful to all the participants in this study. This study was supported by the National Natural Science Foundation of China (30925021), Yunnan Province (云南省高端人 才计划 2009CI119), and the Chinese Academy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000305195400024 |
| 公开日期 | 2012-09-13 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7070]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 2.Department of Dermatology, The First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan, China 3.Yuxi City Center for Disease Control and Prevention, Yuxi 653100, Yunnan, China 4.School of Life Science, Liaoning Normal University, Dalian 116081, Liaoning, China 5.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China |
| 推荐引用方式 GB/T 7714 | Wang D,Feng JQ,Li YY,et al. Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China[J]. HUMAN GENETICS,2012,131(7):1251-1260. |
| APA | Wang D.,Feng JQ.,Li YY.,Zhang DF.,Li XA.,...&Yao YG[*].(2012).Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China.HUMAN GENETICS,131(7),1251-1260. |
| MLA | Wang D,et al."Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China".HUMAN GENETICS 131.7(2012):1251-1260. |
入库方式： OAI收割
来源：昆明动物研究所
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