Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background
文献类型：期刊论文
| 作者 | Yao YG[*]1,2; Kajigaya S1; Feng XM1; Samsel L1; Mccoy JP1; Torelli G3; Young NS1 |
| 刊名 | STEM CELL RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 10期号:3页码:361-370 |
| 通讯作者 | ygyaozh@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Marked sequence variation in the mtDNA control region has been observed in human single CD34(+) cells, which persist in vivo and are present also in differentiated hematopoietic cells. In this study, we analyzed 5071 single CD34(+) cells from 49 individuals (including 31 maternally related members from four families and 18 unrelated donors) in order to determine the mutation spectrum within the mtDNA control region in single cells, as related to aging and family genetic background. Many highly mutated sites among family members were hypervariable sites in the mtDNA control region. Further, CD34(+) cells from members of the same family also shared several unique mtDNA variants, suggesting pedigree-specific occurrence of these variants. Overall age-related accumulation of mtDNA mutations in CD34(+) cells varied in different families, suggesting a specific accumulation pattern, which might be modulated by family genetic background. Our current findings have implications for the occurrence of mtDNA mutations in hematopoietic stem cells and progenitors. |
| 收录类别 | SCI |
| 资助信息 | This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). |
| 语种 | 英语 |
| WOS记录号 | WOS:000318330400009 |
| 公开日期 | 2013-06-13 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7463]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Hematology Branch and Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 3.Dipartimento di Oncologia ed Ematologia, Università di Modena e Reggio Emilia, Policlinico, Via del Pozzo 71, Modena 41100, Italy |
| 推荐引用方式 GB/T 7714 | Yao YG[*],Kajigaya S,Feng XM,et al. Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background[J]. STEM CELL RESEARCH,2013,10(3):361-370. |
| APA | Yao YG[*].,Kajigaya S.,Feng XM.,Samsel L.,Mccoy JP.,...&Young NS.(2013).Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background.STEM CELL RESEARCH,10(3),361-370. |
| MLA | Yao YG[*],et al."Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background".STEM CELL RESEARCH 10.3(2013):361-370. |
入库方式： OAI收割
来源：昆明动物研究所
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