Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands
文献类型：期刊论文
| 作者 | Zhuang XY; Yao YG[*] |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 587期号:11页码:1656-1662 |
| 关键词 | Telomerase G-quadruplex ligand Mitochondrial function Cell apoptosis |
| 通讯作者 | ygyaozh@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | G-quadruplex ligands DODC and TMPyP4 have different binding modes to quadruplex structure and cause cell proliferation arrest. Here we showed that DODC was more efficient in cell growth inhibition than TMPyP4. Both G-quadruplex ligands induced nuclear-cytoplasmic shuttling and accumulation of TERT in mitochondria. This effect was not fully dependent on cellular oxidative stress. DODC induced robust cell apoptosis by perturbing mitochondrial function intensively. Overexpression of TERT could not counteract the effects of DODC on mitochondrial respiratory function. Taken together, our results suggest that interference of mitochondrial function by DODC is one of main targets for its anti-tumor ability. (c) 2013 Federation of European Biochemical Societies |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Ministry of Science and Tech- nology of China (2011CB910900), ‘‘Light in Western China (西部 之光)’’ of the Chinese Academy of Sciences and Yunnan Province (2009CI119). |
| 语种 | 英语 |
| WOS记录号 | WOS:000319445900012 |
| 公开日期 | 2013-07-01 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7531]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Zhuang XY,Yao YG[*]. Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands[J]. FEBS LETTERS,2013,587(11):1656-1662. |
| APA | Zhuang XY,&Yao YG[*].(2013).Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands.FEBS LETTERS,587(11),1656-1662. |
| MLA | Zhuang XY,et al."Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands".FEBS LETTERS 587.11(2013):1656-1662. |
入库方式： OAI收割
来源：昆明动物研究所
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