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No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals
文献类型：期刊论文
| 作者 | Bi R1,2; Zhao L3,4; Zhang C5; Lu WH5; Feng JQ1; Wang YC3,4; Ni JL6; Zhang JT6; Li GD1,7; Hu QX1,2 |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:2页码:444.e5-9 |
| 关键词 | LRRK2 Variants Alzheimer's disease Han Chinese |
| 通讯作者 | ygyaozh@gmail.com ; xuntao26@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | The leucine-rich repeat kinase-2 (LRRK2) gene has been regarded as 1 of the most common genetic causes of Parkinson's disease (PD). We hypothesized that LRRK2-susceptible allele(s) for PD might pose a risk for Alzheimer's disease (AD). In this study, we screened 12 LRRK2 gene variants in 2 independent cohorts from southwestern China (341 AD patients and 435 normal individuals) and eastern China (297 AD patients and 384 normal individuals), to discern the potential association between this gene and AD. No variant was identified to be associated with AD in either case-control sample. As both of the cohorts were of Han Chinese origin, we combined the LRRK2 variant data for the 2 sample sets together (a total of 638 AD patients and 819 normal individuals) and still found no association between the LRRK2 gene and AD, suggesting that LRRK2 gene variants may not affect the development of AD in Han Chinese individuals |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the Ministry of Science and Technology of China (2011CB910900), National Natural Sci- ence Foundation of China (30925021), and the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020000). |
| 语种 | 英语 |
| WOS记录号 | WOS:000328655600028 |
| 公开日期 | 2014-01-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7784]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.University of Chinese Academy of Sciences, Beijing, China 3.Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China 4.State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China 5.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 6.First Geriatric Department, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China 7.School of Life Science, Anhui University, Hefei, Anhui, China |
| 推荐引用方式 GB/T 7714 | Bi R,Zhao L,Zhang C,et al. No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals[J]. NEUROBIOLOGY OF AGING,2014,35(2):444.e5-9. |
| APA | Bi R.,Zhao L.,Zhang C.,Lu WH.,Feng JQ.,...&Li T[*].(2014).No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals.NEUROBIOLOGY OF AGING,35(2),444.e5-9. |
| MLA | Bi R,et al."No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals".NEUROBIOLOGY OF AGING 35.2(2014):444.e5-9. |
入库方式： OAI收割
来源：昆明动物研究所
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