No association between genetic variants of the LRRK2 gene andschizophrenia in Han Chinese
文献类型：期刊论文
| 作者 | Li X1,4; Zhang W[*]1; Zhang C2; Gong W1; Tang JS3; Yi ZH2; Wang D1; Lu WH2; Fang YR2; Chen XG3 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 566期号:X页码:210-215 |
| 关键词 | Mitochondria LRRK2 SNP Schizophrenia Replication Han Chinese |
| 通讯作者 | wzhangxy@gmail.com ; ygyaozh@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Mitochondrial dysfunction was widely reported in schizophrenia patients in recent studies. Leucine-rich repeat kinase 2 (LRRK2) is a mitochondrial protein, and mutations in the LRRK2 gene can induce mitochondrial dysfunction. LRRK2 mutations have been reported to be the most frequent genetic cause of Parkinson's disease (PD). We were interested in whether LRRK2 variants also play a role in schizophrenia. In this study, we genotyped 12 genetic variants (including 4 tag SNPs and 8 disease-associated variants) in the LRRK2 gene in a total of 2449 samples composed of two independent Han Chinese schizophrenia case-control cohorts (486 schizophrenia patients and 480 healthy controls from Hunan Province: 624 schizophrenia patients and 859 healthy controls from Shanghai). We compared the genotype, allele and haplotype frequencies of those SNPs between cases and controls. Statistical analyses revealed no association between LRRK2 variants/haplotypes and schizophrenia in these two schizophrenia case-control cohorts and the combined samples. Our results indicated that the LRRK2 variants are unlikely to be actively involved in schizophrenia in Han Chinese. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02020000), the Ministry of Science and Technology of China (2011CB910900), and the West Light Foundation of the Chinese Academy of Sciences. |
| 语种 | 英语 |
| 公开日期 | 2014-06-04 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7866]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 3.Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China 4.University of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Li X,Zhang W[*],Zhang C,et al. No association between genetic variants of the LRRK2 gene andschizophrenia in Han Chinese[J]. NEUROSCIENCE LETTERS,2014,566(X):210-215. |
| APA | Li X.,Zhang W[*].,Zhang C.,Gong W.,Tang JS.,...&Yao YG[*].(2014).No association between genetic variants of the LRRK2 gene andschizophrenia in Han Chinese.NEUROSCIENCE LETTERS,566(X),210-215. |
| MLA | Li X,et al."No association between genetic variants of the LRRK2 gene andschizophrenia in Han Chinese".NEUROSCIENCE LETTERS 566.X(2014):210-215. |
入库方式： OAI收割
来源：昆明动物研究所
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