Positively selected genes of the Chinese tree shrew (Tupaia belangeri chinensis) locomotion system
文献类型：期刊论文
| 作者 | Fan Y1,2; Yu DD1; Yao YG[*]1,2,3 |
| 刊名 | Zoological Research
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:3页码:240−248 |
| 关键词 | Chinese tree shrew Locomotion system Positively selected genes |
| 通讯作者 | ygyaozh@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | While the recent release of the Chinese tree shrew (Tupaia belangeri chinensis) genome has made the tree shrew an increasingly viable experimental animal model for biomedical research, further study of the genome may facilitate new insights into the applicability of this model. For example, though the tree shrew has a rapid rate of speed and strong jumping ability, there are limited studies on its locomotion ability. In this study we used the available Chinese tree shrew genome information and compared the evolutionary pattern of 407 locomotion system related orthologs among five mammals (human, rhesus monkey, mouse, rat and dog) and the Chinese tree shrew. Our analyses identified 29 genes with significantly high ω (Ka/Ks ratio) values and 48 amino acid sites in 14 genes showed significant evidence of positive selection in the Chinese tree shrew. Some of these positively selected genes, e.g. HOXA6 (homeobox A6) and AVP (arginine vasopressin), play important roles in muscle contraction or skeletal morphogenesis. These results provide important clues in understanding the genetic bases of locomotor adaptation in the Chinese tree shrew. |
| 收录类别 | 其他 |
| 资助信息 | This study was supported by the National 863 Project of China (2012AA021801, 2012AA022402) and grants from Chinese Academy of Sciences (KSCX2-EW-R-11, KSCX2-EW-J23) and Yunnan Province (2013FB071) |
| 语种 | 英语 |
| 公开日期 | 2014-06-06 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7894]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Fan Y,Yu DD,Yao YG[*]. Positively selected genes of the Chinese tree shrew (Tupaia belangeri chinensis) locomotion system[J]. Zoological Research,2014,35(3):240−248. |
| APA | Fan Y,Yu DD,&Yao YG[*].(2014).Positively selected genes of the Chinese tree shrew (Tupaia belangeri chinensis) locomotion system.Zoological Research,35(3),240−248. |
| MLA | Fan Y,et al."Positively selected genes of the Chinese tree shrew (Tupaia belangeri chinensis) locomotion system".Zoological Research 35.3(2014):240−248. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。