Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese
文献类型：期刊论文
| 作者 | Li X1,2; Zhang W1,2; Zhang C3; Yi ZH3; Zhang DF1,2; Gong W1; Tang JS5; Wang D1; Lu WH3; Yao YG[*]1 |
| 刊名 | MOLECULAR GENETICS AND GENOMICS
 |
| 出版日期 | 2015 |
| 卷号 | 290期号:2页码:585-592 |
| 关键词 | PINK1 PARL Mitochondria Schizophrenia Association |
| 通讯作者 | yaoyg@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Schizophrenia is a prevalent psychiatric disorder with a complex etiology. Mitochondrial dysfunction has been frequently reported in schizophrenia. Phosphatase and tension homologue-induced kinase 1 (PINK1) and presenilin-associated rhomboid-like protease (PARL) are mitochondrial proteins, and genetic variants of these two genes may confer genetic susceptibility to schizophrenia by influencing mitochondrial function. In this study, we conducted a two-stage genetic association study to test this hypothesis. We genotyped 4 PINK1 and 5 PARL genetic variants and evaluated the potential association of the 9 SNPs with schizophrenia in two independent case-control cohorts of 2510 Han Chinese individuals. No positive association of common genetic variants of the PINK1 and PARL genes with schizophrenia was identified in our samples after Bonferroni correction. Re-analysis of the newly updated Psychiatric Genetics Consortium (PGC) data sets confirmed our negative result. Intriguingly, one PINK1 SNP (rs10916832), which showed a marginally significant association in only Hunan samples (P = 0.032), is associated with the expression of a schizophrenia susceptible gene KIF17 according to the expression quantitative trait locus (eQTL) analysis. Our study indicated that common genetic variants of the PINK1 and PARL genes are unlikely to be involved in schizophrenia. Further studies are essential to characterize the role of the PINK1 and PARL genes in schizophrenia. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the Strategic Pri- ority Research Program (B) of the Chinese Academy of Sciences (XDB02020000) and the West Light Foundation of the Chinese Acad- emy of Sciences. |
| 语种 | 英语 |
| WOS记录号 | WOS:000351405200016 |
| 公开日期 | 2015-04-17 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8304]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650201, Yunnan, China 3.Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China 4.School of Life Sciences, University of Science and Technology of China, Hefei 230026, Anhui, China 5.Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China |
| 推荐引用方式 GB/T 7714 | Li X,Zhang W,Zhang C,et al. Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese[J]. MOLECULAR GENETICS AND GENOMICS,2015,290(2):585-592. |
| APA | Li X.,Zhang W.,Zhang C.,Yi ZH.,Zhang DF.,...&Gong W.(2015).Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese.MOLECULAR GENETICS AND GENOMICS,290(2),585-592. |
| MLA | Li X,et al."Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese".MOLECULAR GENETICS AND GENOMICS 290.2(2015):585-592. |
入库方式： OAI收割
来源：昆明动物研究所
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