Validating GWAS-Identified Risk Loci for Alzheimer's Disease in Han Chinese Populations
文献类型：期刊论文
| 作者 | Wang HZ1,2; Bi R1,3; Hu QX1,3; Xiang Q1,3; Zhang C4; Zhang DF1,3; Zhang W1,3; Ma XH5,6; Guo WJ5,6; Deng W5,6 |
| 刊名 | MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 53期号:1页码:379-390 |
| 关键词 | GWAS Variants Alzheimer's disease Han Chinese |
| 通讯作者 | yaoyg@mail.kiz.ac.cn. |
| 合作状况 | 其它 |
| 英文摘要 | In recent years, genome-wide association studies (GWASs) have identified many novel susceptible genes/loci for Alzheimer's disease (AD). However, most of these studies were conducted in European and populations of European origin, and limited studies have been performed in Han Chinese. In this study, we genotyped 14 single-nucleotide polymorphisms (SNPs) in eight GWAS-reported AD risk genes in 1509 individuals comprising two independent Han Chinese case-control cohorts. Four SNPs (rs11234495, rs592297, rs676733, and rs3851179) in the PICALM gene were significantly associated with late-onset (LO)-AD in populations from Southwest China, whereas SNPs rs744373 (BIN1), rs9331942 (CLU), and rs670139 (MS4A4E) were linked to LO-AD in populations from East China. In the combined Han Chinese population, positive associations were observed between PICALM, CLU, MS4A4E genes, and LO-AD. The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations. Our study verified the association between PICALM, BIN1, CLU, and MS4A4E variants and AD susceptibility in Han Chinese populations. We also discerned some regional differences concerning AD susceptibility SNPs. |
| 收录类别 | SCI |
| 资助信息 | This studywassupportedbytheStrategicPriorityResearchProgram(B)ofthe Chinese Academy of Sciences (XDB02020000). |
| 语种 | 英语 |
| 公开日期 | 2015-06-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8361]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models andHuman Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 4.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 5.The Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610064, China 6.The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610064, China 7.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Wang HZ,Bi R,Hu QX,et al. Validating GWAS-Identified Risk Loci for Alzheimer's Disease in Han Chinese Populations[J]. MOLECULAR NEUROBIOLOGY,2016,53(1):379-390. |
| APA | Wang HZ.,Bi R.,Hu QX.,Xiang Q.,Zhang C.,...&Yao YG[*].(2016).Validating GWAS-Identified Risk Loci for Alzheimer's Disease in Han Chinese Populations.MOLECULAR NEUROBIOLOGY,53(1),379-390. |
| MLA | Wang HZ,et al."Validating GWAS-Identified Risk Loci for Alzheimer's Disease in Han Chinese Populations".MOLECULAR NEUROBIOLOGY 53.1(2016):379-390. |
入库方式： OAI收割
来源：昆明动物研究所
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