Neprilysin Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese
文献类型：期刊论文
| 作者 | Wang HZ1; Bi R1; Fang YR4; Li T3; Zhang C4; Yao YG[*]1,2,5; Zhang DF1,2; Li GD1,2; Ma XH3 |
| 刊名 | MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 53期号:7页码:4883–4892 |
| 关键词 | Alzheimer’s disease Chinese Genetic susceptibility Neprilysin |
| 通讯作者 | yaoyg@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Alzheimer's disease (AD) is a progressive neurodegenerative disease, with increasing incidence all over the world. Amyloid-β (Aβ) was considered to be the original cause to AD, and many reported pathogenic or risk genes for AD were located in the Aβ generation and degradation pathways.Neprilysin (NEP), insulin-degrading enzyme (IDE), and matrix metalloprotease-9 (MMP-9) are the most important Aβ-degrading proteases. Accumulating genetic evidence suggested that single nucleotide polymorphisms (SNPs) of these genes confer susceptibility to AD in Caucasian populations. In this study, we screened eight SNPs within these three Aβ-degrading protease genes in 1475 individuals of two independent Han Chinese case-control cohorts. SNP rs1816558 of NEP was found to be significantly associated with AD after adjustment for ε4 allele of the apolipoprotein E gene (APOEε4) and the Bonferroni correction. The remaining variants were not associated with risk of AD in Han Chinese sample set. Further data mining revealed that messenger RNA (mRNA) level of NEP substantially increased during the development of AD and was positively correlated with APP expression. The combined results indicated that NEP confers genetic susceptibility to AD in Han Chinese populations. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the Strategic Priority Research Program of Chinese Academy of Sciences (XDB02020003). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9435]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory ofAnimal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 3.The Mental Health Center & Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610064, China 4.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 5.CAS Center for Excellence in Brain Science and Intelligence Technology,ChineseAcademyofSciences,Shanghai200031,Chin |
| 推荐引用方式 GB/T 7714 | Wang HZ,Bi R,Fang YR,et al. Neprilysin Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese[J]. MOLECULAR NEUROBIOLOGY,2016,53(7):4883–4892. |
| APA | Wang HZ.,Bi R.,Fang YR.,Li T.,Zhang C.,...&Ma XH.(2016).Neprilysin Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese.MOLECULAR NEUROBIOLOGY,53(7),4883–4892. |
| MLA | Wang HZ,et al."Neprilysin Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese".MOLECULAR NEUROBIOLOGY 53.7(2016):4883–4892. |
入库方式： OAI收割
来源：昆明动物研究所
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