Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis)
文献类型：期刊论文
| 作者 | Yu DD1; Wu Y1,2; Xu M1,2; Yao YG[*]1,2,3; Xu L1; Fan Y1,2; Peng L1,2 |
| 刊名 | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 60期号:X页码:127-138 |
| 关键词 | TLRs Tree shrew Innate immunity HCV Animal model |
| 通讯作者 | yaoyg@mail.kiz.ac.cn |
| 英文摘要 | In mammals, the toll-like receptors (TLRs) play a major role in initiating innate immune responses against pathogens. Comparison of the TLRs in different mammals may help in understanding the TLR-mediated responses and developing of animal models and efficient therapeutic measures for infectious diseases. The Chinese tree shrew (Tupaia belangeri chinensis), a small mammal with a close relationship to primates, is a viable experimental animal for studying viral and bacterial infections. In this study, we characterized the TLRs genes (tTLRs) in the Chinese tree shrew and identified 13 putative TLRs, which are orthologs of mammalian TLR1-TLR9 and TLR11-TLR13, and TLR10 was a pseudogene in tree shrew. Positive selection analyses using the Maximum likelihood (ML) method showed that tTLR8 and tTLR9 were under positive selection, which might be associated with the adaptation to the pathogen challenge. The mRNA expression levels of tTLRs presented an overall low and tissue-specific pattern, and were significantly upregulated upon Hepatitis C virus (HCV) infection. tTLR4 and tTLR9 underwent alternative splicing, which leads to different transcripts. Phylogenetic analysis and TLR structure prediction indicated that tTLRs were evolutionarily conserved, which might reflect an ancient mechanism and structure in the innate immune response system. Taken together, TLRs had both conserved and unique features in the Chinese tree shrew. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Natural Science Foundation of China (U1402224) and Yunnan Province (2013FB071). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10299]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_中国科学院昆明灵长类研究中心 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China 3.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Yu DD,Wu Y,Xu M,et al. Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis)[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,60(X):127-138. |
| APA | Yu DD.,Wu Y.,Xu M.,Yao YG[*].,Xu L.,...&Peng L.(2016).Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis).DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,60(X),127-138. |
| MLA | Yu DD,et al."Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis)".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 60.X(2016):127-138. |
入库方式： OAI收割
来源：昆明动物研究所
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