Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile
文献类型：期刊论文
| 作者 | Zhang DF[*]1,3; Wang D1; Li YY2; Yao YG[*]1,3 |
| 刊名 | JOURNAL OF DERMATOLOGICAL SCIENCE
 |
| 出版日期 | 2016 |
| 卷号 | 82期号:1页码:18-27 |
| 关键词 | Leprosy Susceptibility gene Enrichment Autoimmune Network |
| 通讯作者 | zhangdengfeng@mail.kiz.ac.cn |
| 英文摘要 | Background: Leprosy is an ancient chronic infection in the skin and peripheral nerves caused by Mycobacterium leprae. The development of leprosy depends on genetic background and the immune status of the host. However, there is no systematic view focusing on the biological pathways, interaction networks and overall expression pattern of leprosy-related immune and genetic factors. Objectives: To identify the hub genes in the center of leprosy genetic network and to provide an insight into immune and genetic factors contributing to leprosy. Methods: We retrieved all reported leprosy-related genes and performed integrative analyses covering gene expression profiling, pathway analysis, protein-protein interaction network, and evolutionary analyses. Results: A list of 123 differentially expressed leprosy related genes, which were enriched in activation and regulation of immune response, was obtained in our analyses. Cross-disorder analysis showed that the list of leprosy susceptibility genes was largely shared by typical autoimmune diseases such as lupus erythematosus and arthritis, suggesting that similar pathways might be affected in leprosy and autoimmune diseases. Protein-protein interaction (PPI) and positive selection analyses revealed a co-evolution network of leprosy risk genes. Conclusions: Our analyses showed that leprosy associated genes constituted a co-evolution network and might undergo positive selection driven by M. leprae. We suggested that leprosy may be a kind of autoimmune disease and the development of leprosy is a matter of defect or over-activation of body immunity. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (31271346). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10310]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China |
| 推荐引用方式 GB/T 7714 | Zhang DF[*],Wang D,Li YY,et al. Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile[J]. JOURNAL OF DERMATOLOGICAL SCIENCE,2016,82(1):18-27. |
| APA | Zhang DF[*],Wang D,Li YY,&Yao YG[*].(2016).Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile.JOURNAL OF DERMATOLOGICAL SCIENCE,82(1),18-27. |
| MLA | Zhang DF[*],et al."Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile".JOURNAL OF DERMATOLOGICAL SCIENCE 82.1(2016):18-27. |
入库方式： OAI收割
来源：昆明动物研究所
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