Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China
文献类型：期刊论文
| 作者 | Wang D1; Li GD1,5; Yu XF3; Long H3; Li YY4; Yao YG[*]1,5; Zhang DF1; Xu L1; Li XA2 |
| 刊名 | INFECTION GENETICS AND EVOLUTION
 |
| 出版日期 | 2016 |
| 卷号 | 45期号:X页码:105–110 |
| 关键词 | Leprosy MAVS MFN2 MITA SNP Susceptibility |
| 通讯作者 | yaoyg@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae), which has massive genomic decay and dependence on host metabolism. Accumulating evidence showed a crucial role of mitochondria in metabolism and innate immunity. We hypothesized that the mitochondrial-related antimicrobial/antiviral immune genes MAVS (mitochondrial antiviral signaling protein), MITA (mediator of IRF3 activation) and MFN2 (mitofusin 2) would confer a risk to leprosy. In this study, we performed a case-control study to analyze 11 tag and/or non-synonymous SNPs of the MAVS, MITA and MFN2 genes in 527 leprosy patients and 583 healthy individuals, and directly sequenced the three genes in 80 leprosy patients with a family history from Yunnan, Southwest China. We found no association between these SNPs and leprosy (including its subtypes) based on the frequencies of alleles, genotypes and haplotypes between the cases and controls. There was also no enrichment of potential pathogenic variants of the three genes in leprosy patients. Our results suggested that genetic variants of the MAVS, MITA and MFN2 genes might not affect the susceptibility to leprosy. |
| 收录类别 | SCI |
| 资助信息 | This study was supported by the National Natural Science Foundation of China (31271346 and 81573034) and Yunnan Province (2014FB177) |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10410]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China 2.Yuxi City Center for Disease Control and Prevention, Yuxi, Yunnan, 653100, China 3.Wenshan Institute of Dermatology, Wenshan, Yunnan, 663000, China 4.Department of Dermatology, the First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, 650032, China 5.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650201, China |
| 推荐引用方式 GB/T 7714 | Wang D,Li GD,Yu XF,et al. Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China[J]. INFECTION GENETICS AND EVOLUTION,2016,45(X):105–110. |
| APA | Wang D.,Li GD.,Yu XF.,Long H.,Li YY.,...&Li XA.(2016).Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China.INFECTION GENETICS AND EVOLUTION,45(X),105–110. |
| MLA | Wang D,et al."Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China".INFECTION GENETICS AND EVOLUTION 45.X(2016):105–110. |
入库方式： OAI收割
来源：昆明动物研究所
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