Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia
文献类型：期刊论文
| 作者 | Luo XJ[*]1; Huang L2,3,4; Li M5; Gan L[*]6,7 |
| 刊名 | SCHIZOPHRENIA RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 143期号:2-3页码:390-392 |
| 通讯作者 | xiongjian_luo@urmc.rochester.edu ; lin_gan@urmc.rochester.edu |
| 合作状况 | 其它 |
| 英文摘要 | Recent genome-wide association studies have identified many promising schizophrenia candidate genes and demonstrated that common polygenic variation contributes to schizophrenia risk. However, whether these genes represent perturbations to a common but limited set of underlying molecular processes (pathways) that modulate risk to schizophrenia remains elusive, and it is not known whether these genes converge on common biological pathways (networks) or represent different pathways. In addition, the theoretical and genetic mechanisms underlying the strong genetic heterogeneity of schizophrenia remain largely unknown. Using 4 well-defined data sets that contain top schizophrenia susceptibility genes and applying protein-protein interaction (PPI) network analysis, we investigated the interactions among proteins encoded by top schizophrenia susceptibility genes. We found proteins encoded by top schizophrenia susceptibility genes formed a highly significant interconnected network, and, compared with random networks, these PPI networks are statistically highly significant for both direct connectivity and indirect connectivity. We further validated these results using empirical functional data (transcriptome data from a clinical sample). These highly significant findings indicate that top schizophrenia susceptibility genes encode proteins that significantly directly interacted and formed a densely interconnected network, suggesting perturbations of common underlying molecular processes or pathways that modulate risk to schizophrenia. Our findings that schizophrenia susceptibility genes encode a highly interconnected protein network may also provide a novel explanation for the observed genetic heterogeneity of schizophrenia, ie, mutation in any member of this molecular network will lead to same functional consequences that eventually contribute to risk of schizophrenia. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313659000025 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://159.226.149.42:8088/handle/152453/7144]  |
| 专题 | 昆明动物研究所_转化基因组 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_科研共享资源 |
| 作者单位 | 1.Flaum Eye Institute and Department of Ophthalmology, University of Rochester, Rochester, New York, USA 2.Nanchang University, Nanchang, Jiangxi, China 3.Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China 4.Gannan Medical University, Ganzhou, Jiangxi, China 5.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 6.Flaum Eye Institute and Department of Ophthalmology, University of Rochester, Rochester, New York, USA 7.College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China |
| 推荐引用方式 GB/T 7714 | Luo XJ[*],Huang L,Li M,et al. Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2013,143(2-3):390-392. |
| APA | Luo XJ[*],Huang L,Li M,&Gan L[*].(2013).Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia.SCHIZOPHRENIA RESEARCH,143(2-3),390-392. |
| MLA | Luo XJ[*],et al."Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia".SCHIZOPHRENIA RESEARCH 143.2-3(2013):390-392. |
入库方式： OAI收割
来源：昆明动物研究所
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