The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population
文献类型：期刊论文
| 作者 | Huang L1; Mo Y2; Sun XJ2; Yu HL3; Li H4; Wu LC[*]5; Li M[*]6 |
| 刊名 | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
 |
| 出版日期 | 2016 |
| 卷号 | 171期号:3页码:396-401 |
| 关键词 | CACNA1C Han Chinese gray matter rs1006737 voxel-based morphometry |
| 通讯作者 | wulichuan@126.com ; limingkiz@gmail.com |
| 合作状况 | 其它 |
| 英文摘要 | The SNP rs1006737 in CACNA1C gene has been significantly associated with psychiatric disorders (e.g., schizophrenia and bipolar disorder) in European populations. In Han Chinese, rs1006737 is also strongly associated with schizophrenia, although the effects of the psychosis risk SNP on related brain functions and structures in this population remain unclear. Here, we examined the association of rs1006737 with gray matter volume in a sample of 278 healthy Han Chinese. A whole-brain voxel-based morphometry (VBM) analysis revealed a significant association in the region around right superior occipital gyrus (family-wise error corrected, P=0.023). Our data provides initial evidence for the involvement of this psychosis genetic risk locus in brain structure variations in Chinese population, and calls for further investigations. |
| 资助信息 | We are grateful to all the voluntary donors of DNA samples in this study. This work was supported by the joint special grant from the Yunnan Provincial ScienceandTechnology Department& Kunm- ing Medical University applied basic research (grant number: 2013FB141). We thank Bing Su’s (Kunming Institute of Zoology) contributionsinthisstudy,wealsothankTianGe’s(Massachusetts GeneralHospital)assistanceduringstatisticalanalysis.Theauthors are pleased to share the data upon request. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9526]  |
| 专题 | 昆明动物研究所_转化基因组 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China 2.Imaging Center, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China 3.Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 4.Department of Urology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 5.School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, China 6.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Huang L,Mo Y,Sun XJ,et al. The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2016,171(3):396-401. |
| APA | Huang L.,Mo Y.,Sun XJ.,Yu HL.,Li H.,...&Li M[*].(2016).The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,171(3),396-401. |
| MLA | Huang L,et al."The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 171.3(2016):396-401. |
入库方式： OAI收割
来源：昆明动物研究所
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