A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations
文献类型：期刊论文
| 作者 | Huang L1,2; Ohi K2; Yue WH4,5; Zhang D4,5; Gao L[*]6; Li M[*]3; Chang H3; Yu H1,4; Wu LC3 |
| 刊名 | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
 |
| 出版日期 | 2016 |
| 卷号 | 171期号:3页码:437-446 |
| 关键词 | ZNF804A schizophrenia bipolar disorder Asians |
| 通讯作者 | gaolei@sdut.edu.cn ; limingkiz@gmail.com |
| 英文摘要 | Common variants in ZNF804A increased the risk of schizophrenia (and bipolar disorder), with low effect sizes in Europeans, which is in line with the polygenic nature of the illnesses, and implies that genetic analyses in small samples may not be sufficient to detect stable results. This notion is supported by the inconsistent replications of ZNF804A variations among individual small Asian samples, indicating the absence of definitive conclusions in this population. We collected psychiatric phenotypic and genetic data from Asian genome-wide association (GWA) and individual replication studies, which include up to 13,452 cases, 17,826 healthy controls, and 680 families, that is, the largest-scale study on ZNF804A in Asian populations to date. The European GWAS risk single nucleotide polymorphism (SNP) rs1344706 was nominally associated with schizophrenia in these Asian samples (one-tailed P=4.26x10(-2), odds ratio [OR]=1.048), and the association was further strengthened when bipolar disorder data was also included (one-tailed P=1.85x10(-2), OR=1.057). Besides, a non-synonymous SNP rs1366842 in the exon 4 of ZNF804A was also associated with schizophrenia (P=9.96x10(-3), OR=1.095). We additionally analyzed other 163 SNPs covering ZNF804A region, but none of them showed any evidence of association. Though the two SNPs did not remain significant if we applied multiple corrections, our analysis should be interpreted as a primary replication study with in prior hypothesis, and rs1344706 and rs1366842 might confer a small but detectable risk of schizophrenia (and bipolar disorder) in Asians. Moreover, the current data suggest the necessity of replication analyses in a large enough scale samples. |
| 资助信息 | Open Project Program of Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences; Grant number: KLMH2014G03; Grant sponsor: National Natural Science Foundation of China; Grant number: 31540034. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10308]  |
| 专题 | 昆明动物研究所_转化基因组 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | 1.First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China 2.Department of Neuropsychiatry, Kanazawa Medical University, Ishikawa, Japan 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 4.Institute of Mental Health, Peking University, Beijing, China 5.Ministry of Health Key Laboratory of Mental Health, Peking University, Beijing, China 6.Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Science, Shandong University of Technology, Zibo, China |
| 推荐引用方式 GB/T 7714 | Huang L,Ohi K,Yue WH,et al. A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2016,171(3):437-446. |
| APA | Huang L.,Ohi K.,Yue WH.,Zhang D.,Gao L[*].,...&Wu LC.(2016).A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,171(3),437-446. |
| MLA | Huang L,et al."A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 171.3(2016):437-446. |
入库方式： OAI收割
来源：昆明动物研究所
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