BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies
文献类型：期刊论文
| 作者 | Li M[*]; Chang H; Xiao X |
| 刊名 | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
 |
| 出版日期 | 2016 |
| 卷号 | 68期号:X页码:218–233 |
| 关键词 | Asian BDNF European Major depressive disorder Val66Met Bipolar disorder |
| 通讯作者 | limingkiz@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-like effects in animal models and may be implicated in the etiology of mood-related phenotypes. A functional polymorphism (Val66Met) in the BDNF gene was demonstrated to influence BDNF's secretion and function, as well as mood and cognitive related phenotypes. However, previous genetic association studies of Val66Metpolymorphism in the clinical risk of mood disorders have been complicated, possibly due to phenotypic diversity, underpowered statisticalassociation or ancestry-specific effects. Here, we collected mood phenotypic and genetic data in over 90,000 individuals from diverse ethnic groups and conducted a systematic meta-analysis. The results showed that the Val66Met polymorphism was significantly associated with BPD in Europeans (Pmeta=0.0029, OR=1.136), but not in Asians (Pmeta=0.443). Also, it appears that the risk for MDD conferred by BDNF is waning, as the Val66Met variant was not associated with MDD in either European or Asian samples (Pmeta>0.5). |
| 收录类别 | SCI |
| 资助信息 | This work was supported by CAS Pioneer Hundred Talents Program. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10533]  |
| 专题 | 昆明动物研究所_转化基因组 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 作者单位 | Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Li M[*],Chang H,Xiao X. BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2016,68(X):218–233. |
| APA | Li M[*],Chang H,&Xiao X.(2016).BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,68(X),218–233. |
| MLA | Li M[*],et al."BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 68.X(2016):218–233. |
入库方式： OAI收割
来源：昆明动物研究所
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