Rare and common variants at 16p11.2 are associated with schizophrenia
文献类型:期刊论文
作者 | Chang H; Li LY; Li M[*]; Xiao X[*] |
刊名 | Schizophrenia Research |
出版日期 | 2016 |
卷号 | X期号:X页码:XX-XX |
关键词 | 16p11.2 duplication Copy number variation GWAS Schizophrenia |
通讯作者 | limingkiz@mail.kiz.ac.cn ; xiaoxiao2@mail.kiz.ac.cn |
合作状况 | 其它 |
英文摘要 | Recent studies suggest that both common and rare variants are involved in the genetic risk of schizophrenia. Using a Cochran-Mantel-Haenszel (CMH) adjusted meta-analysis in 36,676 schizophrenia patients and 48,331 healthy controls from 24 independent samples, we identify the microduplications at 16p11.2 locus (29.6-30.2Mb, hg19) to be strongly associated with the illness (P value<2.2×10-16, CHM-adjusted OR=10.79). The frequency of this microduplication is significantly higher in schizophrenia patients (0.267%) comparing to healthy controls (0.025%). Further, using the largest published genome-wide association study (GWAS) data (36,989 cases and 113,075 controls), we show that common variants at the 16p11.2 locus are also significantly associated with schizophrenia (e.g., rs12691307, P value=4.55×10-11, OR=1.073). These results confirm the link between 16p11.2 genomic region and genetic risk of schizophrenia. |
资助信息 | This work was supported by CAS Pioneer Hundred Talents Program (M.L.). |
收录类别 | SCI |
语种 | 英语 |
源URL | [http://159.226.149.26:8080/handle/152453/10680] |
专题 | 昆明动物研究所_转化基因组 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
作者单位 | Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China |
推荐引用方式 GB/T 7714 | Chang H,Li LY,Li M[*],et al. Rare and common variants at 16p11.2 are associated with schizophrenia[J]. Schizophrenia Research,2016,X(X):XX-XX. |
APA | Chang H,Li LY,Li M[*],&Xiao X[*].(2016).Rare and common variants at 16p11.2 are associated with schizophrenia.Schizophrenia Research,X(X),XX-XX. |
MLA | Chang H,et al."Rare and common variants at 16p11.2 are associated with schizophrenia".Schizophrenia Research X.X(2016):XX-XX. |
入库方式: OAI收割
来源:昆明动物研究所
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