Depletion of Myostatin b Promotes somatic Growth and Lipid Metabolism in Zebrafish
文献类型：期刊论文
| 作者 | Gao, Yanping1,2; Dai, Ziru1,3; Shi, Chuang1,2; Zhai, Gang1; Jin, Xia1; He, Jiangyan1; Lou, Qiyong1; Yin, Zhan1 |
| 刊名 | FRONTIERS IN ENDOCRINOLOGY
 |
| 出版日期 | 2016-07-04 |
| 卷号 | 7 |
| 关键词 | zebrafish myostatin myogenesis lipogenesis energy metabolism |
| ISSN号 | 1664-2392 |
| 英文摘要 | Myostatin (MSTN) is a negative regulator of myogenesis in vertebrates. Depletion of mstn resulted in elevated muscle growth in several animal species. However, the report on the complete ablation of mstn in teleost fish has not yet become available. In this study, two independent mstnb-deficient mutant lines in zebrafish were generated with the TALENs technique. In the mstnb-deficient zebrafish, enhanced muscle growth with muscle fiber hyperplasia was achieved. Beginning at the adult stage (80 days postfertilization), the mstnb-deficient zebrafish exhibited increased circumferences and body weights compared with the wild-type sibling control fish. Although the overall total lipid/body weight ratios remained similar between the mstnb-deficient zebrafish and the control fish, the distribution of lipids was altered. The size of the visceral adipose tissues became smaller while more lipids accumulated in skeletal muscle in the mstnb-deficient zebrafish than in the wild-type control fish. Based on the transcriptional expression profiles, our results revealed that lipid metabolism, including lipolysis and lipogenesis processes, was highly activated in the mstnb-deficient zebrafish, which indicated the transition of energy metabolism from protein-dependent to lipid-dependent in mstnb-deficient zebrafish. Our mstnb-deficient model could be valuable in understanding not only the growth trait regulation in teleosts but also the mechanisms of teleost energy metabolism. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | HORMONE-SENSITIVE LIPASE ; WHITE ADIPOSE-TISSUE ; SKELETAL-MUSCLE ; TRANSGENIC ZEBRAFISH ; INSULIN-RESISTANCE ; GENE ; EXPRESSION ; PATHWAY ; LIVER ; BROWN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385292200001 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/28595]  |
| 专题 | 水生生物研究所_藻类生物学及应用研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qinzhou Univ, Coll Food Engn, Guangxi Key Lab Beibu Gulf Marine Biodivers Conse, Key Lab Dev & High Value Utilizat Beibu Gulf Seaf, Qinzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yanping,Dai, Ziru,Shi, Chuang,et al. Depletion of Myostatin b Promotes somatic Growth and Lipid Metabolism in Zebrafish[J]. FRONTIERS IN ENDOCRINOLOGY,2016,7. |
| APA | Gao, Yanping.,Dai, Ziru.,Shi, Chuang.,Zhai, Gang.,Jin, Xia.,...&Yin, Zhan.(2016).Depletion of Myostatin b Promotes somatic Growth and Lipid Metabolism in Zebrafish.FRONTIERS IN ENDOCRINOLOGY,7. |
| MLA | Gao, Yanping,et al."Depletion of Myostatin b Promotes somatic Growth and Lipid Metabolism in Zebrafish".FRONTIERS IN ENDOCRINOLOGY 7(2016). |
入库方式： OAI收割
来源：水生生物研究所
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