中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility

文献类型:期刊论文

作者Piao, Chengji1,2,3; Deng, Xiaofei1,2; Wang, Xingyue1,2; Yuan, Yiran4; Liu, Zhengkui1; Liang, Jing1
刊名BEHAVIOURAL BRAIN RESEARCH
出版日期2017-01-15
卷号317期号:0页码:16-26
ISSN号0166-4328
关键词Single prolonged stress Set-shifting Medial prefrontal cortex Nucleus accumbens
英文摘要

The medial prefrontal cortex (mPFC) and its output area, the nucleus accumbens (NAc), are implicated in mediating attentional set-shifting. Patients with posttraumatic stress disorder (PTSD) exhibit difficulties in the disengagement of attention from traumatic cues, which is associated with impairments in set shifting ability. However, unknown is whether alterations in corticostriatal function underlie deficits in this behavioral flexibility in individuals with PTSD. An animal model of single prolonged stress (SPS) has been partially validated as a model for PTSD, in which SPS rats recapitulate the pathophysiological abnormalities and behavioral characteristics of PTSD. In the present study, we firstly found that exposure to SPS impaired the ability in the shift from visual-cue learning to place response discrimination in rats. Conversely, SPS induced no effect on a place-to-cue set-shifting performance. Based on SPS-impaired set-shifting model, we used Western blot and immunofluorescent approaches to clarify SPS-induced alternations in synaptic plasticity and neuronal activation in the mPFC and NAc. Rats that were subjected to SPS exhibited a large increase in pSer845-G1uA1 and total G1uA1 levels in the mPFC, while no significant change in the NAc. We further found that exposure to SPS significantly decreased c-Fos expression in the NAc core but not the shell after set-shifting behavior. Whereas, enhanced c-Fos expression was observed in prelimbic and infralimbic cortices. Collectively, these findings suggest that abnormal hyperactivity in the mPFC and dysfunction in the NAc core underlie long-term deficits in executive function after traumatic experience, which might play an important role in the development of PTSD symptoms. (C) 2016 Elsevier B.V. All rights reserved.

WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]SINGLE-PROLONGED STRESS ; RAT MODEL ; COGNITIVE FLEXIBILITY ; AMPA RECEPTORS ; SPATIAL MEMORY ; DISORDER ; PTSD ; PHOSPHORYLATION ; STRIATUM ; PLASTICITY
收录类别SCI
语种英语
WOS记录号WOS:000389086700002
源URL[http://ir.psych.ac.cn/handle/311026/20940]  
专题心理研究所_中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Piao, Chengji,Deng, Xiaofei,Wang, Xingyue,et al. Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility[J]. BEHAVIOURAL BRAIN RESEARCH,2017,317(0):16-26.
APA Piao, Chengji,Deng, Xiaofei,Wang, Xingyue,Yuan, Yiran,Liu, Zhengkui,&Liang, Jing.(2017).Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility.BEHAVIOURAL BRAIN RESEARCH,317(0),16-26.
MLA Piao, Chengji,et al."Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility".BEHAVIOURAL BRAIN RESEARCH 317.0(2017):16-26.

入库方式: OAI收割

来源:心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。