Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility
文献类型:期刊论文
作者 | Piao, Chengji1,2,3; Deng, Xiaofei1,2; Wang, Xingyue1,2; Yuan, Yiran4; Liu, Zhengkui1; Liang, Jing1 |
刊名 | BEHAVIOURAL BRAIN RESEARCH |
出版日期 | 2017-01-15 |
卷号 | 317期号:0页码:16-26 |
ISSN号 | 0166-4328 |
关键词 | Single prolonged stress Set-shifting Medial prefrontal cortex Nucleus accumbens |
英文摘要 | The medial prefrontal cortex (mPFC) and its output area, the nucleus accumbens (NAc), are implicated in mediating attentional set-shifting. Patients with posttraumatic stress disorder (PTSD) exhibit difficulties in the disengagement of attention from traumatic cues, which is associated with impairments in set shifting ability. However, unknown is whether alterations in corticostriatal function underlie deficits in this behavioral flexibility in individuals with PTSD. An animal model of single prolonged stress (SPS) has been partially validated as a model for PTSD, in which SPS rats recapitulate the pathophysiological abnormalities and behavioral characteristics of PTSD. In the present study, we firstly found that exposure to SPS impaired the ability in the shift from visual-cue learning to place response discrimination in rats. Conversely, SPS induced no effect on a place-to-cue set-shifting performance. Based on SPS-impaired set-shifting model, we used Western blot and immunofluorescent approaches to clarify SPS-induced alternations in synaptic plasticity and neuronal activation in the mPFC and NAc. Rats that were subjected to SPS exhibited a large increase in pSer845-G1uA1 and total G1uA1 levels in the mPFC, while no significant change in the NAc. We further found that exposure to SPS significantly decreased c-Fos expression in the NAc core but not the shell after set-shifting behavior. Whereas, enhanced c-Fos expression was observed in prelimbic and infralimbic cortices. Collectively, these findings suggest that abnormal hyperactivity in the mPFC and dysfunction in the NAc core underlie long-term deficits in executive function after traumatic experience, which might play an important role in the development of PTSD symptoms. (C) 2016 Elsevier B.V. All rights reserved. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Behavioral Sciences ; Neurosciences |
研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology |
关键词[WOS] | SINGLE-PROLONGED STRESS ; RAT MODEL ; COGNITIVE FLEXIBILITY ; AMPA RECEPTORS ; SPATIAL MEMORY ; DISORDER ; PTSD ; PHOSPHORYLATION ; STRIATUM ; PLASTICITY |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000389086700002 |
源URL | [http://ir.psych.ac.cn/handle/311026/20940] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Piao, Chengji,Deng, Xiaofei,Wang, Xingyue,et al. Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility[J]. BEHAVIOURAL BRAIN RESEARCH,2017,317(0):16-26. |
APA | Piao, Chengji,Deng, Xiaofei,Wang, Xingyue,Yuan, Yiran,Liu, Zhengkui,&Liang, Jing.(2017).Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility.BEHAVIOURAL BRAIN RESEARCH,317(0),16-26. |
MLA | Piao, Chengji,et al."Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility".BEHAVIOURAL BRAIN RESEARCH 317.0(2017):16-26. |
入库方式: OAI收割
来源:心理研究所
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