Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography
文献类型：期刊论文
| 作者 | Wang, Tao1; Yang, Haiyan2 ; Qiu, Ruchen1; Huang, Shaohua2
|
| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2016-11-09 |
| 卷号 | 944页码:70-77 |
| 关键词 | Chiral imidazolium Ionic liquid Chiral stationary phase High-performance liquid chromatography Enantioseparation |
| 英文摘要 | Two novel chiral stationary phases (CSPs) were prepared by bonding chiral imidazoliums on the surface of silica gel. The chiral imidazoles were derivatized from chiral amines, 1-phenylethylamine and 1-(1naphthyl) ethylamine. The obtained CSPs were characterized by Fourier Transform Infrared (FT-IR) spectroscopy and elemental analysis (EA), demonstrating the bonding densities of CSP 1 and CSP 2 were 0.43 mmol g(-1) and 0.40 mmol g(-1), respectively. These two CSPs could be used to availably separate 8 pharmaceuticals, 7 mandelic acid/its derivatives, 2 1-phenylethylamine derivatives, 1 1,10-bi-2-naphthol, and 1 camphorsulfonic acid in high-performance liquid chromatography (HPLC). It is found that CSP 1 could effectively enantioseparate most chiral analytes, especially the acidic components, while CSP 2 could enantiorecognize all chiral analytes, although a number of components did not achieve baseline separation. Additionally, the effects of mobile phase composition, mobile phase pH and salt content, chiral selector structures, and analyte structures on the enantiorecognitions of the two CSPs were investigated. It is found that high acetonitrile content in mobile phases was conducive to enantior-ecognition. Mobile phase pH and salt content could alter the retention behaviors of different enantiomers of the same chiral compound, resulting in better enantioresolution. Moreover, both chiral selector structures and substituted groups of analytes played a significant role in the separation of chiral solutes. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Analytical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | NATURAL AMINO-ACIDS ; IONIC LIQUIDS ; CAPILLARY-ELECTROPHORESIS ; CYCLODEXTRINS ; RECOGNITION ; LIGANDS ; SEPARATION ; CHEMISTRY ; MEDIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385841200008 |
| 源URL | [http://ir.qibebt.ac.cn/handle/337004/9059]  |
| 专题 | 青岛生物能源与过程研究所_条件保障部公共实验室 |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Tao,Yang, Haiyan,Qiu, Ruchen,et al. Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography[J]. ANALYTICA CHIMICA ACTA,2016,944:70-77. |
| APA | Wang, Tao,Yang, Haiyan,Qiu, Ruchen,&Huang, Shaohua.(2016).Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography.ANALYTICA CHIMICA ACTA,944,70-77. |
| MLA | Wang, Tao,et al."Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography".ANALYTICA CHIMICA ACTA 944(2016):70-77. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。