CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation
文献类型：期刊论文
| 作者 | Zhang, Kun1,2; Xu, Huixiong2; Chen, Hangrong1; Jia, Xiaoqing1; Zheng, Shuguang2; Cai, Xiaojun1; Wang, Ronghui3; Mou, Juan1; Zheng, Yuanyi3; Shi, Jianlin1 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:11页码:1291-1302 |
| 关键词 | Nanobomb inertial cavitation low intensity ultrasound panc-1 pancreatic cancer dual-responsive CO2 release |
| 英文摘要 | Noninvasive and targeted physical treatment is still desirable especially for those cancerous patients. Herein, we develop a new physical treatment protocol by employing CO2 bubbling-based 'nanobomb' system consisting of low-intensity ultrasound (1.0 W/cm(2)) and a well-constructed pH/temperature dual-responsive CO2 release system. Depending on the temperature elevation caused by exogenous low-intensity therapeutic ultrasound irradiation and the low pH caused by the endogenous acidic-environment around/within tumor, dual-responsive CO2 release system can quickly release CO2 bubbles, and afterwards, the generated CO2 bubbles waves will timely explode before dissolution due to triggering by therapeutic ultrasound waves. Related bio-effects (e.g., cavitation, mechanical, shock waves, etc) caused by CO2 bubbles' explosion effectively induce instant necrosis of panc-1 cells and blood vessel destruction within panc-1 tumor, and consequently inhibit the growth of panc-1 solid tumor, simultaneously minimizing the side effects to normal organs. This new physiotherapy employing CO2 bubbling-based 'nanobomb' system promises significant potentials in targetedly suppressing tumors, especially for those highly deadly cancers. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Medicine, Research & Experimental |
| 研究领域[WOS] | Research & Experimental Medicine |
| 关键词[WOS] | MESOPOROUS SILICA NANOPARTICLES ; ALTERNATING MAGNETIC-FIELD ; FOCUSED ULTRASOUND ; INDUCED APOPTOSIS ; CARCINOMA CELLS ; CARBON-DIOXIDE ; IN-VITRO ; THERAPEUTIC APPLICATIONS ; PHOTOTHERMAL THERAPY ; CONTRAST AGENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000386249900004 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/22078]  |
| 专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Ding Xi Rd, Shanghai 200050, Peoples R China 2.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Med Ultrasound, Shanghai 200072, Peoples R China 3.Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Kun,Xu, Huixiong,Chen, Hangrong,et al. CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation[J]. THERANOSTICS,2015,5(11):1291-1302. |
| APA | Zhang, Kun.,Xu, Huixiong.,Chen, Hangrong.,Jia, Xiaoqing.,Zheng, Shuguang.,...&Shi, Jianlin.(2015).CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation.THERANOSTICS,5(11),1291-1302. |
| MLA | Zhang, Kun,et al."CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation".THERANOSTICS 5.11(2015):1291-1302. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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