Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization
文献类型：期刊论文
| 作者 | Fu, Qi-Wei1; Zi, Yun-Peng1; Xu, Wei1; Zhou, Rong1; Cai, Zhu-Yun1; Zheng, Wei-Jie1; Chen, Feng2; Qian, Qi-Rong1 |
| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2016 |
| 卷号 | 11 |
| 关键词 | calcium phosphate water-soluble drug nanofibers drug release electrospinning |
| 英文摘要 | Calcium phosphate-based biomaterials have been well studied in biomedical fields due to their outstanding chemical and biological properties which are similar to the inorganic constituents in bone tissue. In this study, amorphous calcium phosphate (ACP) nanoparticles were prepared by a precipitation method, and used for preparation of ACP-poly(D,L-lactic acid) (ACP-PLA) nanofibers and water-soluble drug-containing ACP-PLA nanofibers by electrospinning. Promoting the encapsulation efficiency of water-soluble drugs in electrospun hydrophobic polymer nanofibers is a common problem due to the incompatibility between the water-soluble drug molecules and hydrophobic polymers solution. Herein, we used a native biomolecule of lecithin as a biocompatible surfactant to overcome this problem, and successfully prepared water-soluble drug-containing ACP-PLA nanofibers. The lecithin and ACP nanoparticles played important roles in stabilizing water-soluble drug in the electrospinning composite solution. The electrospun drug-containing ACP-PLA nanofibers exhibited fast mineralization in simulated body fluid. The ACP nanoparticles played the key role of seeds in the process of mineralization. Furthermore, the drug-containing ACP-PLA nanofibers exhibited sustained drug release which simultaneously occurred with the in situ mineralization in simulated body fluid. The osteoblast-like (MG63) cells with spreading filopodia were well observed on the as-prepared nanofibrous mats after culturing for 24 hours, indicating a high cytocompatibility. Due to the high biocompatibility, sustained drug release, and fast mineralization, the as-prepared composite nanofibers may have potential applications in water-soluble drug loading and release for tissue engineering. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Nanoscience & Nanotechnology ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 关键词[WOS] | BONE DEFECT REPAIR ; COMPOSITE NANOFIBERS ; FIBROUS SCAFFOLDS ; PHOSPHATE ; HYDROXYAPATITE ; BIOMINERALIZATION ; FABRICATION ; INTERFACE ; SURFACE ; FIBERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385045200002 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/22026]  |
| 专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
| 作者单位 | 1.Second Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200003, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Qi-Wei,Zi, Yun-Peng,Xu, Wei,et al. Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2016,11. |
| APA | Fu, Qi-Wei.,Zi, Yun-Peng.,Xu, Wei.,Zhou, Rong.,Cai, Zhu-Yun.,...&Qian, Qi-Rong.(2016).Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization.INTERNATIONAL JOURNAL OF NANOMEDICINE,11. |
| MLA | Fu, Qi-Wei,et al."Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization".INTERNATIONAL JOURNAL OF NANOMEDICINE 11(2016). |
入库方式： OAI收割
来源：上海硅酸盐研究所
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