Cerium Oxide-Incorporated Calcium Silicate Coating Protects MC3T3-E1 Osteoblastic Cells from H2O2-Induced Oxidative Stress
文献类型：期刊论文
| 作者 | Li, Kai; Xie, Youtao; You, Mingyu; Huang, Liping; Zheng, Xuebin |
| 刊名 | BIOLOGICAL TRACE ELEMENT RESEARCH
 |
| 出版日期 | 2016-11-01 |
| 卷号 | 174期号:1页码:198-207 |
| 关键词 | Oxidative stress CeO2 Calcium silicate Osteoblast Antioxidant |
| 英文摘要 | Oxidative stress regulates cellular functions in multiple pathological conditions, including bone formation by osteoblastic cells. In this work, the protective effects of cerium oxide (CeO2)-incorporated calcium silicate (CeO2-CS) coating on the response of osteoblasts to H2O2-induced oxidative stress and the related mechanism were examined. CeO2 incorporation significantly improved osteoblast viability and reduced cell apoptosis caused by H2O2 when compared with the control. H2O2-induced reduction of differentiation marker alkaline phosphatase (ALP) was recovered in the presence of the CeO2-CS coating. The above effects were mediated by the antioxidant effect of CeO2. The CeO2-CS coating immersed in 0.1 mM H2O2 aqueous solution was able to degrade 64 % of it in 1 week. In addition, CeO2 incorporation decreased reactive oxygen species (ROS) production and suppressed malondialdehyde (MDA) formation in H2O2-treated osteoblasts. Taken together, CeO2-CS biomedical coatings with antioxidant property would be promising for bone regeneration under oxidative stress. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | HYDROGEN-PEROXIDE ; ALKALINE-PHOSPHATASE ; MIMETIC ACTIVITY ; IN-VITRO ; NANOPARTICLES ; DAMAGE ; STATE ; DIFFERENTIATION ; MINERALIZATION ; PROLIFERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385132300024 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/22027]  |
| 专题 | 上海硅酸盐研究所_特种无机涂层重点实验室_期刊论文 |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat, 1295 Dingxi Rd, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Kai,Xie, Youtao,You, Mingyu,et al. Cerium Oxide-Incorporated Calcium Silicate Coating Protects MC3T3-E1 Osteoblastic Cells from H2O2-Induced Oxidative Stress[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2016,174(1):198-207. |
| APA | Li, Kai,Xie, Youtao,You, Mingyu,Huang, Liping,&Zheng, Xuebin.(2016).Cerium Oxide-Incorporated Calcium Silicate Coating Protects MC3T3-E1 Osteoblastic Cells from H2O2-Induced Oxidative Stress.BIOLOGICAL TRACE ELEMENT RESEARCH,174(1),198-207. |
| MLA | Li, Kai,et al."Cerium Oxide-Incorporated Calcium Silicate Coating Protects MC3T3-E1 Osteoblastic Cells from H2O2-Induced Oxidative Stress".BIOLOGICAL TRACE ELEMENT RESEARCH 174.1(2016):198-207. |
入库方式： OAI收割
来源：上海硅酸盐研究所
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