Chemical stability and osteogenic activity of plasma-sprayed boron-modified calcium silicate-based coatings
文献类型：期刊论文
| 作者 | Lu, Xiang1,2; Li, Kai1; Xie, Youtao1; Huang, Liping1; Zheng, Xuebin1 |
| 刊名 | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
 |
| 出版日期 | 2016-11-01 |
| 卷号 | 27期号:11 |
| 英文摘要 | In recent years, CaSiO3 bio-ceramic coatings have attracted great attention because of their good bioactivity. However, their high degradation rates in physiological environment restrict their practical applications. In this work, boron-modified CaSiO3 ceramic (Ca11Si4B2O22, B-CS) coating was developed on Ti substrates by plasmaspraying technique attempting to obtain enhanced chemical stability and osteogenic activity. The B-CS coating possessed significantly increased chemical stability due to the introduction of boron and consequently the modified crystal structure, while maintaining good bioactivity. Scanning electron microscope and immunofluorescence studies showed that better cellular adhesion and extinctive filopodia-like processes were observed on the B-CS coating. Compared with the pure CaSiO3 (CS) coating, the B-CS coating promoted MC3T3-E1 cells attachment and proliferation. In addition, enhanced collagen I (COL-I) secretion, alkaline phosphatase activity, and extracellular matrix mineralization levels were detected from the B-CS coating. According to RT-PCR results, notable up-regulation expressions of mineralized tissue-related genes, such as runt-related transcription factor 2 (Runx2), bone sialoprotein and osteocalcin, and bone morphogenetic protein 7 (BMP-7) were observed on the B-CS coating compared with the CS coating. The above results suggested that Ca11Si4B2O22 coatings possess excellent osteogenic activity and might be a promising candidate for orthopedic applications. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | BIOLOGICAL-PROPERTIES ; BIOCERAMIC COATINGS ; BONE REGENERATION ; CRYSTAL-STRUCTURE ; CELL-GROWTH ; STEM-CELLS ; IN-VITRO ; PROLIFERATION ; DIFFERENTIATION ; GLASSES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000384473000007 |
| 源URL | [http://ir.sic.ac.cn/handle/331005/22139]  |
| 专题 | 上海硅酸盐研究所_特种无机涂层重点实验室_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat, 1295 Dingxi Rd, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Xiang,Li, Kai,Xie, Youtao,et al. Chemical stability and osteogenic activity of plasma-sprayed boron-modified calcium silicate-based coatings[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2016,27(11). |
| APA | Lu, Xiang,Li, Kai,Xie, Youtao,Huang, Liping,&Zheng, Xuebin.(2016).Chemical stability and osteogenic activity of plasma-sprayed boron-modified calcium silicate-based coatings.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,27(11). |
| MLA | Lu, Xiang,et al."Chemical stability and osteogenic activity of plasma-sprayed boron-modified calcium silicate-based coatings".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 27.11(2016). |
入库方式： OAI收割
来源：上海硅酸盐研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。