On-line monitoring of pharmaceutical production processes by means of near infrared spectrum with hidden Markov model
文献类型：期刊论文
| 作者 | Ma, C.; Peng, Z.X.; Xu, H.K.; Du, R. |
| 刊名 | Control and Intelligent Systems
 |
| 出版日期 | 2010 |
| 卷号 | 38期号:1页码:8-15 |
| 英文摘要 | In recent years, a few pharmaceutical companies have started to use on-line monitoring for quality assurance. The state-of-the-art online monitoring method is based on near infrared (NIR) spectrum. Because the pharmaceutical production process is a dynamic process, the NIR method used alone may not work very well. This paper introduces a new method for on-line monitoring of pharmaceutical production process. It consists of several steps: First, it uses partial least squares (PLS) to extract the features from NIR spectrum. Next, it uses hidden Markov model (HMM) to model the production process. Based on two sets of powder blending experiments, it is found that the new method gives more precise information to help us control the process. It is believed that the proposed method is effective and can be used for various pharmaceutical production processes |
| 收录类别 | EI |
| 原文出处 | http://www.actapress.com/PaperInfo.aspx?PaperID=38678 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/2699]  |
| 专题 | 深圳先进技术研究院_集成所 |
| 作者单位 | Control and Intelligent Systems |
| 推荐引用方式 GB/T 7714 | Ma, C.,Peng, Z.X.,Xu, H.K.,et al. On-line monitoring of pharmaceutical production processes by means of near infrared spectrum with hidden Markov model[J]. Control and Intelligent Systems,2010,38(1):8-15. |
| APA | Ma, C.,Peng, Z.X.,Xu, H.K.,&Du, R..(2010).On-line monitoring of pharmaceutical production processes by means of near infrared spectrum with hidden Markov model.Control and Intelligent Systems,38(1),8-15. |
| MLA | Ma, C.,et al."On-line monitoring of pharmaceutical production processes by means of near infrared spectrum with hidden Markov model".Control and Intelligent Systems 38.1(2010):8-15. |
入库方式： OAI收割
来源：深圳先进技术研究院
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