Tracking time-varying cerebral autoregulation in response to changes in respiratory PaCO2
文献类型：期刊论文
| 作者 | Jia Liu; M David Simpson; Jingyu Yan; Robert Allen |
| 刊名 | PHYSIOLOGICAL MEASUREMENT
 |
| 出版日期 | 2010 |
| 卷号 | 31期号:10页码:1291-1307 |
| 英文摘要 | Cerebral autoregulation has been studied by linear filter systems, with arterial blood pressure (ABP) as the input and cerebral blood flow velocity (CBFV-from transcranial Doppler Ultrasound) as the output. The current work extends this by using adaptive filters to investigate the dynamics of time-varyingcerebral autoregulation during step-wise changes in arterial PaCO2. Cerebral autoregulation was transiently impaired in 11 normal adult volunteers, by switching inspiratory air to a CO2/air mixture (5% CO2, 30% O-2 and 65% N-2) for approximately 2 min and then back to the ambient air, causing step-wise changes in end-tidal CO2 (EtCO2). Simultaneously, ABP and CBFV were recorded continuously. Simulated data corresponding to the same protocol were also generated using an established physiological model, in order to refine the signal analysis methods. Autoregulation was quantified by the time-varying phase lead, estimated from the adaptive filter model. The adaptive filter was able to follow rapid changes in autoregulation, as was confirmed in the simulated data. In the recorded signals, there was a slow decrease in autoregulatory function following the step-wise increase in PaCO2(but this did not reach a steady state within approximately 2 min of recording), with a more rapid change in autoregulation on return to normocapnia. Adaptive filter modelling was thus able to demonstrate time-varying autoregulation. It was further noted that impairment and recovery of autoregulationduring transient increases in EtCO2 occur in an asymmetric manner, which should be taken into account when designing experimental protocols for the study of autoregulation. |
| 收录类别 | SCI |
| 原文出处 | http://iopscience.iop.org/0967-3334/31/10/001 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/2751]  |
| 专题 | 深圳先进技术研究院_集成所 |
| 作者单位 | PHYSIOLOGICAL MEASUREMENT |
| 推荐引用方式 GB/T 7714 | Jia Liu,M David Simpson,Jingyu Yan,et al. Tracking time-varying cerebral autoregulation in response to changes in respiratory PaCO2[J]. PHYSIOLOGICAL MEASUREMENT,2010,31(10):1291-1307. |
| APA | Jia Liu,M David Simpson,Jingyu Yan,&Robert Allen.(2010).Tracking time-varying cerebral autoregulation in response to changes in respiratory PaCO2.PHYSIOLOGICAL MEASUREMENT,31(10),1291-1307. |
| MLA | Jia Liu,et al."Tracking time-varying cerebral autoregulation in response to changes in respiratory PaCO2".PHYSIOLOGICAL MEASUREMENT 31.10(2010):1291-1307. |
入库方式： OAI收割
来源：深圳先进技术研究院
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