Dynamic Cerebral Autoregulation Is Heterogeneous in Different Subtypes of Acute Ischemic Stroke
文献类型：期刊论文
| 作者 | Zhen-Ni Guo; Jia Liu; Yingqi Xing; Shuo Yan; Cunling Lv; Hang Jin; Yi Yang |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2014 |
| 英文摘要 | Background and Purpose Stroke of large-artery atherosclerosis and small-artery occlusion are two main subtypes of stroke according to TOAST classification. The underlying mechanisms of how these two subtypes affect dynamic cerebral autoregulation (dCA) might be heterogeneous, resulting in varied clinical conditions and outcomes. We therefore studied the pattern of dCA in these two subtypes. Methods Forty-one patients with acute unilateral middle cerebral artery (MCA) territory stroke (15 with ipsilateral large-artery atherosclerosis and 26 with small-artery occlusion) and 20 healthy volunteers were enrolled. Non-invasive continuous cerebral blood flow velocity and arterial blood pressure were recorded simultaneously from each subject in supine position using transcranial Doppler on MCA bilaterally and servo-controlled plethysmograph on the middle finger, respectively. Transfer function analysis was applied to derive autoregulatory parameters, gain, phase difference (PD), and slope of step response. Results In the large-artery atherosclerosis group, PD in affected hemisphere was 42.9±18.5 degree, which is significantly lower than the unaffected hemisphere (72.4±29.9 degree, P<0.01), and the healthy group (P<0.01). However, PD is similar in the unaffected hemisphere and healthy group (P>0.1). In the small-artery occlusion group, PD in the affected hemisphere was similar to that in the contralateral hemisphere (33.8±17.9 vs. 32.6±21.1 degree, P>0.1), both sides were significantly lower than the healthy group (all P<0.001).The results of the slope of step response agree with the findings in PD. Conclusions DCA in different subtypes of acute ischemic stroke is heterogeneous, which might be attributed to the varied pathologic changes of cerebral blood vessels. |
| 收录类别 | SCI |
| 原文出处 | http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0093213&representation=PDF |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/5440]  |
| 专题 | 深圳先进技术研究院_集成所 |
| 作者单位 | PLOS ONE |
| 推荐引用方式 GB/T 7714 | Zhen-Ni Guo,Jia Liu,Yingqi Xing,et al. Dynamic Cerebral Autoregulation Is Heterogeneous in Different Subtypes of Acute Ischemic Stroke[J]. PLOS ONE,2014. |
| APA | Zhen-Ni Guo.,Jia Liu.,Yingqi Xing.,Shuo Yan.,Cunling Lv.,...&Yi Yang.(2014).Dynamic Cerebral Autoregulation Is Heterogeneous in Different Subtypes of Acute Ischemic Stroke.PLOS ONE. |
| MLA | Zhen-Ni Guo,et al."Dynamic Cerebral Autoregulation Is Heterogeneous in Different Subtypes of Acute Ischemic Stroke".PLOS ONE (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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