Myocardial Iron Loading Assessment by Automatic Left Ventricle Segmentation with Morphological Operations and Geodesic Active Contour on T2* images
文献类型：期刊论文
| 作者 | Yun-gang Luo; Jacky KL Ko; Lin Shi; Yuefeng Guan; Linong Li; Jing Qin; Pheng-Ann Heng; Winnie CW Chu; Defeng Wang |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2015 |
| 英文摘要 | Myocardial iron loading thalassemia patients could be identified using T2* magnetic resonance images (MRI). To quantitatively assess cardiac iron loading, we proposed an effective algorithm to segment aligned free induction decay sequential myocardium images based on morphological operations and geodesic active contour (GAC). Nine patients with thalassemia major were recruited (10 male and 16 female) to undergo a thoracic MRI scan in the short axis view. Free induction decay images were registered for T2* mapping. The GAC were utilized to segment aligned MR images with a robust initialization. Segmented myocardium regions were divided into sectors for a region-based quantification of cardiac iron loading. Our proposed automatic segmentation approach achieve a true positive rate at 84.6% and false positive rate at 53.8%. The area difference between manual and automatic segmentation was 25.5% after 1000 iterations. Results from T2* analysis indicated that regions with intensity lower than 20 ms were suffered from heavy iron loading in thalassemia major patients. The proposed method benefited from abundant edge information of the free induction decay sequential MRI. Experiment results demonstrated that the proposed method is feasible in myocardium segmentation and was clinically applicable to measure myocardium iron loading. |
| 收录类别 | SCI |
| 原文出处 | http://www.nature.com/articles/srep12438 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6677]  |
| 专题 | 深圳先进技术研究院_集成所 |
| 作者单位 | Scientific Reports |
| 推荐引用方式 GB/T 7714 | Yun-gang Luo,Jacky KL Ko,Lin Shi,et al. Myocardial Iron Loading Assessment by Automatic Left Ventricle Segmentation with Morphological Operations and Geodesic Active Contour on T2* images[J]. Scientific Reports,2015. |
| APA | Yun-gang Luo.,Jacky KL Ko.,Lin Shi.,Yuefeng Guan.,Linong Li.,...&Defeng Wang.(2015).Myocardial Iron Loading Assessment by Automatic Left Ventricle Segmentation with Morphological Operations and Geodesic Active Contour on T2* images.Scientific Reports. |
| MLA | Yun-gang Luo,et al."Myocardial Iron Loading Assessment by Automatic Left Ventricle Segmentation with Morphological Operations and Geodesic Active Contour on T2* images".Scientific Reports (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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