Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control
文献类型：期刊论文
| 作者 | Li, Weifeng; Chen, Ziyi; Yan, Nan; Jones, Jeffery A.; Guo, Zhiqiang; Huang, Xiyan; Chen, Shaozhen; Liu, Peng; Liu, Hanjun |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 英文摘要 | Temporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and deficits in the cortical processing of auditory information. Whether TLE compromises auditorymotor integration for voice control, however, remains largely unknown. To address this question, eventrelated potentials (ERPs) and vocal responses to vocal pitch errors (1/2 or 2 semitones upward) heard in auditory feedback were compared across 28 patients with TLE and 28 healthy controls. Patients with TLE produced significantly larger vocal responses but smaller P2 responses than healthy controls. Moreover, patients with TLE exhibited a positive correlation between vocal response magnitude and baseline voice variability and a negative correlation between P2 amplitude and disease duration. Graphical network analyses revealed a disrupted neuronal network for patients with TLE with a significant increase of clustering coefficients and path lengths as compared to healthy controls. These findings provide strong evidence that TLE is associated with an atypical integration of the auditory and motor systems for vocal pitch regulation, and that the functional networks that support the auditorymotor processing of pitch feedback errors differ between patients with TLE and healthy controls. |
| 收录类别 | SCI |
| 原文出处 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928116/ |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/9817]  |
| 专题 | 深圳先进技术研究院_集成所 |
| 作者单位 | SCIENTIFIC REPORTS |
| 推荐引用方式 GB/T 7714 | Li, Weifeng,Chen, Ziyi,Yan, Nan,et al. Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control[J]. SCIENTIFIC REPORTS,2016. |
| APA | Li, Weifeng.,Chen, Ziyi.,Yan, Nan.,Jones, Jeffery A..,Guo, Zhiqiang.,...&Liu, Hanjun.(2016).Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control.SCIENTIFIC REPORTS. |
| MLA | Li, Weifeng,et al."Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control".SCIENTIFIC REPORTS (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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