The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control
文献类型：期刊论文
| 作者 | Xiyan Huang; Xi Chen; Nan Yan; Jeffery A. Jones; Emily Q. Wang; Ling Chen; Zhiqiang Guo; Weifeng Li; Peng Liu; Hanjun Liu |
| 刊名 | Human Brain Mapping
 |
| 出版日期 | 2016 |
| 英文摘要 | Several studies have shown sensorimotor deficits in speech processing in individuals with idiopathic Parkinson’s disease (PD). The underlying neural mechanisms, however, remain poorly understood. In the present event-related potential (ERP) study, 18 individuals with PD and 18 healthy controls were exposed to frequency-altered feedback (FAF) while producing a sustained vowel and listening to the playback of their own voice. Behavioral results revealed that individuals with PD produced significantly larger vocal compensation for pitch feedback errors than healthy controls, and exhibited a significant positive correlation between the magnitude of their vocal responses and the variability of their unaltered vocal pitch. At the cortical level, larger P2 responses were observed for individuals with PD compared with healthy controls during active vocalization due to left-lateralized enhanced activity in the superior and inferior frontal gyrus, premotor cortex, inferior parietal lobule, and superior temporal gyrus. These two groups did not differ, however, when they passively listened to the playback of their own voice. Individuals with PD also exhibited larger P2 responses during active vocalization when compared with passive listening due to enhanced activity in the inferior frontal gyrus, precental gyrus, postcentral gyrus, and middle temporal gyrus. This enhancement effect, however, was not observed for healthy controls. These findings provide neural evidence for the abnormal auditory–vocal integration for voice control in individuals with PD, which may be caused by their deficits in the detection and correction of errors in voice auditory feedback. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/hbm.23306/full |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/9821]  |
| 专题 | 深圳先进技术研究院_集成所 |
| 作者单位 | Human Brain Mapping |
| 推荐引用方式 GB/T 7714 | Xiyan Huang,Xi Chen,Nan Yan,et al. The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control[J]. Human Brain Mapping,2016. |
| APA | Xiyan Huang.,Xi Chen.,Nan Yan.,Jeffery A. Jones.,Emily Q. Wang.,...&Hanjun Liu.(2016).The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control.Human Brain Mapping. |
| MLA | Xiyan Huang,et al."The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control".Human Brain Mapping (2016). |
入库方式： OAI收割
来源：深圳先进技术研究院
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