Staphylococcal enterotoxin C2 promotes osteogenesis and suppresses osteoclastogenesis of human mesenchymal stem cells
文献类型：期刊论文
| 作者 | Wei-ming Fu; Xiao Zhu; Hua Wang; Wei-mao Wang; Ju-yu Chen; Yan Liang; Jin-fang Zhang; Hsiang-fu Kung |
| 刊名 | EXPERIMENTAL CELL RESEARCH
 |
| 出版日期 | 2014 |
| 英文摘要 | As a super-antigen, staphylococcal enterotoxin C2 (SEC2) stimulates the release of massive inflammatory cytokines such as interferon-gamma (IFN-gamma), interleukin-1 (IL-1) and interleukin-2 (IL-2) which are documented to implicate osteoblast differentiation. In the present study, SEC2 was found to significantly improve the osteoblast differentiation by up-regulating BMP2 and Runx2/Cbfa1 expression. Interferon (IFN)-inducible gene IFI16, a co-activator of Runx2/Cbfa1, was also activated by SEC2 in the osteoblast differentiation. In addition, exogenous introduction of SEC2 stimulated OPG expression and suppressed RANK!, suggesting suppression of osteoclastogenesis in hMSCs. Therefore, our results displayed that SEC2 plays an important role in the commitment of MSC to the osteoblast and it might be a potential new therapeutic candidate for bone regeneration. |
| 收录类别 | SCI |
| 原文出处 | http://www.sciencedirect.com/science/article/pii/S0014482713005259 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6231]  |
| 专题 | 深圳先进技术研究院_南沙所 |
| 作者单位 | EXPERIMENTAL CELL RESEARCH |
| 推荐引用方式 GB/T 7714 | Wei-ming Fu,Xiao Zhu,Hua Wang,et al. Staphylococcal enterotoxin C2 promotes osteogenesis and suppresses osteoclastogenesis of human mesenchymal stem cells[J]. EXPERIMENTAL CELL RESEARCH,2014. |
| APA | Wei-ming Fu.,Xiao Zhu.,Hua Wang.,Wei-mao Wang.,Ju-yu Chen.,...&Hsiang-fu Kung.(2014).Staphylococcal enterotoxin C2 promotes osteogenesis and suppresses osteoclastogenesis of human mesenchymal stem cells.EXPERIMENTAL CELL RESEARCH. |
| MLA | Wei-ming Fu,et al."Staphylococcal enterotoxin C2 promotes osteogenesis and suppresses osteoclastogenesis of human mesenchymal stem cells".EXPERIMENTAL CELL RESEARCH (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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