1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Wei-ming Fu; Wei-mao Wang; Hua Wang; Xiao Zhu; Yan Liang; Hsiang-fu Kung; Jin-fang Zhang |
| 刊名 | CELL BIOLOGY INTERNATIONAL
 |
| 出版日期 | 2014 |
| 英文摘要 | We previously showed that the small molecule 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone (TDP) induces apoptosis in hepatocellular carcinoma (HCC) by suppressing Hsp27 expression, although the mechanism is not fully understood. To investigate the functional association between TDP and Hsp27 protein in HCC, recombinant Hsp27 protein was incubated with TDP at room temperature, and assayed by mass spectrum (MS) and natural electrophoresis. TDP effectively stimulated Hsp27 to form aggregates ex vitro, leading to suppression of its chaperone activity. The aggregates were degraded by the ubiquitin-proteasome (UPS) pathway. TDP directly interacted with Asp17 and Phe55 in chain C of Hsp27 on the basis of bioinformatic prediction. In conclusion, Hsp27 is a direct target of TDP in its anti-cancer activity, which provides strong support for a clinical application. |
| 收录类别 | SCI |
| 原文出处 | http://onlinelibrary.wiley.com/doi/10.1002/cbin.10193/full |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6232]  |
| 专题 | 深圳先进技术研究院_南沙所 |
| 作者单位 | CELL BIOLOGY INTERNATIONAL |
| 推荐引用方式 GB/T 7714 | Wei-ming Fu,Wei-mao Wang,Hua Wang,et al. 1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma[J]. CELL BIOLOGY INTERNATIONAL,2014. |
| APA | Wei-ming Fu.,Wei-mao Wang.,Hua Wang.,Xiao Zhu.,Yan Liang.,...&Jin-fang Zhang.(2014).1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma.CELL BIOLOGY INTERNATIONAL. |
| MLA | Wei-ming Fu,et al."1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma".CELL BIOLOGY INTERNATIONAL (2014). |
入库方式： OAI收割
来源：深圳先进技术研究院
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