MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells.
文献类型：期刊论文
| 作者 | Fu WM; Tang LP; Zhu X; Lu YF; Zhang YL; Lee WY; Wang H; Yu Y; Liang WC; Ko CH |
| 刊名 | Apoptosis
 |
| 出版日期 | 2015 |
| 英文摘要 | Traditional Chinese medicine is recently emerged as anti-cancer therapy or adjuvant with reduced side-effects and improved quality of life. In the present study, an active ingredient, 1,6,7-trihydroxyxanthone (THA), derived from Goodyera oblongifolia was found to strongly suppress cell growth and induce apoptosis in liver cancer cells. MicroRNAs are a group of small non-coding RNAs that regulate gene expression at post-transcriptional levels. Our results demonstrated that miR-218 was up-regulated and oncogene Bmi-1 was down-regulated by THA treatment. Further investigation showed that THA-induced-miR-218 up-regulation could lead to activation of tumor suppressor P16(Ink4a) and P14(ARF), the main down-stream targets of Bmi-1. In conclusion, THA might be a potential anti-cancer drug candidate, at least in part, through the activation of miR-218 and suppression of Bmi-1 expression. |
| 收录类别 | SCI |
| 原文出处 | http://link.springer.com/article/10.1007%2Fs10495-014-1047-3 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/7548]  |
| 专题 | 深圳先进技术研究院_南沙所 |
| 作者单位 | Apoptosis |
| 推荐引用方式 GB/T 7714 | Fu WM,Tang LP,Zhu X,et al. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells.[J]. Apoptosis,2015. |
| APA | Fu WM.,Tang LP.,Zhu X.,Lu YF.,Zhang YL.,...&Zhang JF..(2015).MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells..Apoptosis. |
| MLA | Fu WM,et al."MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells.".Apoptosis (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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