Processing of visually-evoked innate fear by a non-canonical thalamic pathway
文献类型：期刊论文
| 作者 | Wei PF; Liu N; Zhang ZJ; Liu XM; Tang YQ; He XB; Wu BF; Zhou Z; Liu YH; Li J |
| 刊名 | Nature Communications
 |
| 出版日期 | 2015 |
| 英文摘要 | The ability of animals to respond to life-threatening stimuli is essential for survival. Although vision provides one of the major sensory inputs for detecting threats across animal species, the circuitry underlying defensive responses to visual stimuli remains poorly defined. Here, we investigate the circuitry underlying innate defensive behaviours elicited by predator-like visual stimuli in mice. Our results demonstrate that neurons in the superior colliculus (SC) are essential for a variety of acute and persistent defensive responses to overhead looming stimuli. Optogenetic mapping revealed that SC projections to the lateral posterior nucleus (LP) of the thalamus, a non-canonical polymodal sensory relay, are sufficient to mimic visually evoked fear responses. In vivo electrophysiology experiments identified a di-synaptic circuit from SC through LP to the lateral amygdale (Amg), and lesions of the Amg blocked the full range of visually evoked defensive responses. Our results reveal a novel collicular–thalamic– Amg circuit important for innate defensive responses to visual threats. |
| 收录类别 | SCI |
| 原文出处 | http://www.nature.com/ncomms/2015/150409/ncomms7756/full/ncomms7756.html |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/6817]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 作者单位 | Nature Communications |
| 推荐引用方式 GB/T 7714 | Wei PF,Liu N,Zhang ZJ,et al. Processing of visually-evoked innate fear by a non-canonical thalamic pathway[J]. Nature Communications,2015. |
| APA | Wei PF.,Liu N.,Zhang ZJ.,Liu XM.,Tang YQ.,...&Wang LP.(2015).Processing of visually-evoked innate fear by a non-canonical thalamic pathway.Nature Communications. |
| MLA | Wei PF,et al."Processing of visually-evoked innate fear by a non-canonical thalamic pathway".Nature Communications (2015). |
入库方式： OAI收割
来源：深圳先进技术研究院
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